1192-92-3

Basic information

• Product Name: 2,5-Diazabicyclo[2.2.2]octane Dihydrochloride
• Synonyms: 2,5-Diazabicyclo[2.2.2]octane Dihydrochloride
• CAS NO: 1192-92-3
• Molecular Formula: C₆H₁₂N₂*2ClH
• Molecular Weight: 185.09476
• Mol File: 1192-92-3.mol

Chemical Properties

• Boiling Point: 196.3°Cat760mmHg
• Flash Point: 92.9°C
• Appearance: /
• Density: 0.975g/cm³
• Vapor Pressure: 0.402mmHg at 25°C
• Refractive Index: 1.475
• CAS DataBase Reference: 2,5-Diazabicyclo[2.2.2]octane Dihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Diazabicyclo[2.2.2]octane Dihydrochloride(1192-92-3)
• EPA Substance Registry System: 2,5-Diazabicyclo[2.2.2]octane Dihydrochloride(1192-92-3)

Safety Data

• Hazardous Substances Data: 1192-92-3(Hazardous Substances Data)

Usage

Uses

Used in Chemical Catalysts:
2,5-Diazabicyclo[2.2.2]octane Dihydrochloride is used as a catalyst in a wide range of organic reactions due to its strong basic nature and steric hindrance. It facilitates the formation of foams and resins, enhancing the efficiency and selectivity of these processes.
Used in Pharmaceutical Manufacturing:
In the pharmaceutical industry, 2,5-Diazabicyclo[2.2.2]octane Dihydrochloride is utilized in the manufacturing processes of various drugs. Its ability to act as a catalyst and its solubility in different solvents make it a valuable component in the synthesis of pharmaceutical compounds.
Used in Solvent Systems:
Due to its high solubility in both water and organic solvents, 2,5-Diazabicyclo[2.2.2]octane Dihydrochloride is employed in solvent systems to improve the solubility of other compounds, facilitating their use in various chemical reactions and processes.
Used in Research and Development:
In research settings, 2,5-Diazabicyclo[2.2.2]octane Dihydrochloride is used as a reagent and catalyst to explore new chemical reactions and syntheses. Its unique properties allow researchers to investigate novel pathways and mechanisms in organic chemistry.

Downstream Products

• 1059701-66-4 (1aR,12bS)-8-cyclohexyl-11-methoxy-1a-((5-(2-methoxyethyl)-2,5-diazabicyclo[2.2.2]oct-2-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylic acid 
• 1059700-13-8 (1aR,12bS)-8-cyclohexyl-N-(isopropylsulfonyl)-11-methoxy-1a-((5-(2-methoxyethyl)-2,5-diazabicyclo[2.2.2]oct-2-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide 
• 1059701-53-9 (1aR,12bS)-8-cyclohexyl-N-(isopropylsulfonyl)-11-methoxy-1a-((5-methyl-2,5-diazabicyclo[2.2.2]oct-2-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide 
• 1059701-65-3 Tert-butyl (1aR,12bS)-8-cyclohexyl-11-methoxy-1a-((5-(2-methoxyethyl)-2,5-diazabicyclo[2.2.2]oct-2-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylate 
• 1059701-51-7 Tert-butyl (1aR,12bS)-8-cyclohexyl-11-methoxy-1a-((5-methyl-2,5-diazabicyclo[2.2.2]oct-2-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylate 
• 1059701-52-8 (1aR,12bS)-8-cyclohexyl-11-methoxy-1a-((5-methyl-2,5-diazabicyclo[2.2.2]oct-2-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylic acid 
• 1059701-50-6 tert-butyl (1aR,12bS)-8-cyclohexyl-1a-(2,5-diazabicyclo[2.2.2]oct-2-ylcarbonyl)-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylate 
• 858671-91-7 tert‐butyl 2,5‐diazabicyclo[2.2.2]octane‐2‐carboxylate 

Relevant articles and documents

INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, AND 1,2-BENZISOTHIAZOLES, AND PREPARATION AND USES THEREOF

The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds for example, indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, which act as ligands for the α7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.