119209-56-2

Upstream product

• 160206-92-8 2-acetyl-4-(2-nitro-phenyl)-3-oxo-butyric acid methyl ester 
• 22751-23-1 (2-nitrophenyl)acetyl chloride 
• 3740-52-1 2-(2-nitrophenyl)acetic acid 
• 38330-80-2 monomethyl monopotassium malonate 

Downstream Products

• 363159-41-5 {2-[2-(2-Nitro-phenyl)-acetyl]-phenyl}-acetic acid methyl ester 
• 119209-39-1 4-Methyl-2-(2-nitrobenzyl)nicotinsaeure-methylester 
• 119209-41-5 2-(2-Aminobenzyl)-4-methylnicotinsaeure-methylester 
• 119209-33-5 (Z)-3-Amino-4-(2-nitrophenyl)crotonsaeure-methylester 

Relevant academic research and scientific papers

Expedient synthesis of 3-hydroxyisoquinolines and 2-hydroxy-1,4- naphthoquinones via one-pot aryne acyl-alkylation/condensation

A convenient method is disclosed for the synthesis of both 3-hydroxyisoquinolines and 2-hydroxy-1,4-naphthoquinones from β-ketoesters using a one-pot aryne acyl-alkylation/condensation procedure. When performed in conjunction with a one-step method for the synthesis of the β-ketoester substrates, this method provides a new route to these polyaromatic structures in only two steps from commercially available carboxylic acid starting materials. The utility of this approach is demonstrated in the synthesis of the atropisomeric P,N-ligand, QUINAP. The Royal Society of Chemistry 2009.

Synthesis of pyrazole derivatives 4(1H)-quinolone and 4-chloroquinoline by thermolysis of arylaminomethylene Meldrum's acid derivative

Efficient syntheses of 4(1H)-quinolone 1 and 4-chloroquinoline 2 by thermolysis of arylaminomethylene Meldrum's acid derivative starting from 2-nitrophenyl acetic acid.