363159-41-5

Upstream product

• 16535-88-9 (2-acetyk-phenyl)-acetic acid methyl ester 
• 1493-27-2 ortho-nitrofluorobenzene 
• 57486-69-8 methyl 2-(2-bromophenyl)acetate 
• 1026415-28-0 [2-(1-butoxy-vinyl)-phenyl]-acetic acid methyl ester 
• 119209-56-2 methyl 4-(2-nitrophenyl)-3-oxobutyrate 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 

Downstream Products

• 363159-42-6 2-hydroxy-3-(2-nitrophenyl)naphthalene-1,4-dione 

Relevant academic research and scientific papers

Expedient synthesis of 3-hydroxyisoquinolines and 2-hydroxy-1,4- naphthoquinones via one-pot aryne acyl-alkylation/condensation

A convenient method is disclosed for the synthesis of both 3-hydroxyisoquinolines and 2-hydroxy-1,4-naphthoquinones from β-ketoesters using a one-pot aryne acyl-alkylation/condensation procedure. When performed in conjunction with a one-step method for the synthesis of the β-ketoester substrates, this method provides a new route to these polyaromatic structures in only two steps from commercially available carboxylic acid starting materials. The utility of this approach is demonstrated in the synthesis of the atropisomeric P,N-ligand, QUINAP. The Royal Society of Chemistry 2009.

Palladium mediated total synthesis of o-acetylphenylacetic acids: A general route to indolo[2,3-b]naphthalene-6,11-diones

Here we describe a new, efficient general synthesis of o-acetylphenylacetic acids by Heck palladium-catalyzed arylation of n-butyl vinyl ether with o-bromophenylacetic acids, and its application to the synthesis of indolo[2,3-b]naphthalene-6,11-diones.