1192159-94-6Relevant academic research and scientific papers
Regioselective Synthesis of 2-Substituted Indoles from Benzotriazoles and Alkynes by Photoinitiated Denitrogenation
Teders, Michael,Pitzer, Lena,Buss, Stefan,Glorius, Frank
, p. 4053 - 4056 (2017)
Herein, we describe a photoinitiated and regioselective synthesis of 2-substituted indoles under mild reaction conditions. This biologically privileged scaffold was accessed in good yields from N-aroylbenzotriazoles, a quencher class previously identified using our mechanism-based luminescence screening, and terminal alkynes in the presence of a photocatalyst and blue light irradiation. This straightforward protocol displays a broad substrate scope and functional group tolerance. Furthermore, the mildness and robustness of the reaction were assessed by the application of an additive-based robustness screen. The determination of the reaction quantum yield and Stern-Volmer studies support the proposed photoinitiated radical chain mechanism.
Preparation method of N-acyl indole compound
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Paragraph 0031-0037, (2021/06/06)
The invention discloses a preparation method of an N-acyl indole compound. The preparation method comprises the following steps: adding a palladium catalyst, potassium carbonate, a carbon monoxide substitute, 2-alkynylaniline and an aryl iodide into an or
Copper-catalyzed N-arylation/hydroamin(d)ation domino synthesis of indoles and its application to the preparation of a Chekl/KDR kinase inhibitor pharmacophore
Ackermann, Lutz,Barfuesser, Sebastian,Potukuchi, Harish K.
supporting information; experimental part, p. 1064 - 1072 (2010/03/03)
Inexpensive copper catalysts allow for efficient syntheses of N-aryl-, N-acyl-, or N-H-(aza)in-doles starting from ortho-alkynylbromoarenes. The broad scope of this domino N-arylation/hydro-amin(d)ation process is highlighted by the synthesis of highly fu
