119216-22-7

Usage

Uses

Used in Pharmaceutical Industry:
(E)-4-(1-methyl-1H-indol-3-yl)but-3-en-2-one is used as an intermediate in the synthesis of various pharmaceuticals for its versatile chemical structure and potential pharmacological properties.
Used in Organic Synthesis:
(E)-4-(1-methyl-1H-indol-3-yl)but-3-en-2-one is used as a building block in organic synthesis due to its double bond and ketone functional group, which allow for further chemical reactions and the creation of a wide range of compounds.
Used in Neurological Research:
(E)-4-(1-methyl-1H-indol-3-yl)but-3-en-2-one is used as a research compound for studying its potential role in the regulation of serotonin and melatonin levels in the brain, which could lead to the development of treatments for neurological disorders.
Used in Anti-Cancer Research:
(E)-4-(1-methyl-1H-indol-3-yl)but-3-en-2-one is used as a potential anti-cancer agent, with ongoing research into its effectiveness in targeting and treating cancer cells.

Upstream product

• 19012-03-4 N-methyl-3-formylindole 
• 67-64-1 acetone 
• 620-02-0 5-Methylfurfural 
• 1358528-26-3 (2-bromophenyl)(methyl)(5-methylfuran-2-ylmethyl)amine 
• 615-36-1 2-bromoaniline 
• 31951-75-4 (E)-4-(1H-indol-3-yl)but-3-en-2-one 
• 74-88-4 methyl iodide 
• 487-89-8 Indole-3-carboxaldehyde 

Downstream Products

• 1330579-09-3 (E)-4-(1-methyl-1H-indol-3-yl)-6-phenylhex-5-en-2-one 
• 374690-05-8 5-(tert-butyl-dimethyl-silanyloxy)-3-(1-methyl-1H-indol-3-yl)-cyclohexa-1,4-diene-1,2-dicarboxylic acid dimethyl ester 

Relevant academic research and scientific papers

Br?nsted Acid Catalyzed Homoconjugate Addition of Organotrifluoroborates to Arylated Cyclopropyl Ketones

A novel and practical homoconjugate addition of alkenyl, alkynyl, heteroaryl, and aryl trifluoroborates to arylated cyclopropyl ketones to synthesize γ,γ-disubstituted ketones is reported. A preliminary mechanistic proposal involving ketone protonation, a

A novel entry to functionalized benzofurans and indoles via palladium(0)-catalyzed arylative dearomatization of furans

A novel entry to functionalized benzofurans and indoles from furans in moderate to good yields has been developed. This protocol involves palladium(0)-catalyzed dearomatizing intramolecular arylation of the furan ring, formation of a π-allylic palladium complex, furan ring opening, and a β-hydride elimination sequence.

Enantioselective conjugate addition of alkenylboronic acids to indole-appended enones

An enantioselective addition of alkenylboronic acids and alkynylboronic esters to unprotected indole-appended enones is reported. This transformation proceeds with high enantioselectivity and high product yields via the use of catalytic amounts of 3,3′-bis(pentafluorophenyl)-BINOL and Mg(Ot-Bu) 2. A range of α-branched indole derivatives are available from the transformation.

Diels-Alder reactivity and some synthetic applications of (E)-1-(3-indolyl)-3-tert-butyldimethylsiloxy-1,3-butadienes

The preparation of (E)-1-(3-indolyl)-3-tert-butyldimethylsiloxy-1,3-butadienes and their Diels-Alder reaction with selected dienophiles at room temperature is described. The utility of these heteroaryldienes for the construction of different (3-indolyl)-planar systems is shown by the synthesis of a grooved analogue of arcyriaflavin A.