119220-54-1

Basic information

• Product Name: 1-benzyl-2-(trimethylsilyl)-2-cyclopentanone
• CAS NO: 119220-54-1
• Molecular Weight: 246.425
• Mol File: 119220-54-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-benzyl-2-(trimethylsilyl)-2-cyclopentanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-2-(trimethylsilyl)-2-cyclopentanone(119220-54-1)
• EPA Substance Registry System: 1-benzyl-2-(trimethylsilyl)-2-cyclopentanone(119220-54-1)

Safety Data

• Hazardous Substances Data: 119220-54-1(Hazardous Substances Data)

Upstream product

• 930-30-3 cyclopent-2-enone 
• 18000-27-6 trimethylsilyllithium 
• 100-39-0 benzyl bromide 

Downstream Products

• 88364-64-1 C₁₇H₂₅NO₂Si 
• 88364-65-2 6-phenylhex-4-enenitrile 
• 119220-55-2 (2R,3R)-2-Benzyl-3-trimethylsilanyl-cyclopentanone oxime 
• 119220-55-2 (2R,3R)-2-Benzyl-3-trimethylsilanyl-cyclopentanone oxime 

Relevant articles and documents

SILICON-DIRECTED BECKMANN FRAGMENTATION

The selective fragmentation reactions of β-trimethylsilylketoximes have been proved to proceed effectively with acid catalysts giving the corresponding nitriles.Cyclic silylketoximes gave unsaturated nitriles.The fragmentation in the Beckmann rearrangement is completely controlled and directed by a trimethylsilyl group to lead the regio- and stereo-specific formation of the double bond.The catalytic fragmentation proceeds with the combination of trimethylsilyl ketoxime acetates and trimethylsilyl trifluoromethanesulfonate giving nitriles in high yields.Excellent stereospecificity of the fragmentation based on the stereochemical outcome was discussed.Simple stereo-controlled synthetic approach to some insect pheromones is also described.