1192223-76-9Relevant academic research and scientific papers
Synthesis of two new hemisynthetic diterpenylhydroquinones from natural iiwf-Labdanes
Catalan, Luis Espinoza,Marin, Karen Catalan,Villegas, Alejandro Madrid,Altamirano, Hector Carrasco,Garcia, Joan Villena,Fritis, Mauricio Cuellar
, p. 2181 - 2194 (2009)
The synthesis and structural determination of two new diterpenylhydroquinones: 2β-acetoxy-15-phenyl-(22,25-dihydroxy)-ent-labda- 8(17),13(￡)-diene (1) and 2β-hydroxy- 15-phenyl-(22,25-dihydroxy)- ent-labda-8(17),13(E)-diene is reported (2). These compound
Synthesis and antitumor activity of diterpenylhydroquinone derivatives of natural ent-labdanes
Catalan, Luis Espinoza,Maturana, Evelyn Baeza,Marin, Karen Catalan,Olivares, Mauricio Osorio,Altamirano, Hector Carrasco,Fritis, Mauricio Cuellar,Garcia, Joan Villena
experimental part, p. 6502 - 6511 (2010/12/18)
Two new compounds 2β-acetoxy-15-phenyl-(22,25-acetoxy)-ent-labda-8(17) , 13(E)-diene (9) and 2β-hydroxy-15-phenyl-(22,24,26-trimethoxy)-ent-labda- 8(17),13(E)-diene (10) have been prepared by an Electrophilic Aromatic Substitution (EAS) reaction between diterpenyl allylic alcohols and 1,4-hydroquinone or 1,3,5-trimethoxybenzene using BF3·Et 2O as a catalyst. These compounds, along with a series of natural ent-labdanes 3-8, have been evaluated for their in vitro cytotoxic activities against cultured human cancer cells of PC-3 and DU-145 human prostate cancer, MCF-7 and MDA-MB-231 breast carcinoma and dermal human fibroblasts (DHF). Some compounds displayed inhibition at μM IC50 values.
