1245925-66-9Relevant academic research and scientific papers
Synthesis and antitumor activity of diterpenylhydroquinone derivatives of natural ent-labdanes
Catalan, Luis Espinoza,Maturana, Evelyn Baeza,Marin, Karen Catalan,Olivares, Mauricio Osorio,Altamirano, Hector Carrasco,Fritis, Mauricio Cuellar,Garcia, Joan Villena
experimental part, p. 6502 - 6511 (2010/12/18)
Two new compounds 2β-acetoxy-15-phenyl-(22,25-acetoxy)-ent-labda-8(17) , 13(E)-diene (9) and 2β-hydroxy-15-phenyl-(22,24,26-trimethoxy)-ent-labda- 8(17),13(E)-diene (10) have been prepared by an Electrophilic Aromatic Substitution (EAS) reaction between diterpenyl allylic alcohols and 1,4-hydroquinone or 1,3,5-trimethoxybenzene using BF3·Et 2O as a catalyst. These compounds, along with a series of natural ent-labdanes 3-8, have been evaluated for their in vitro cytotoxic activities against cultured human cancer cells of PC-3 and DU-145 human prostate cancer, MCF-7 and MDA-MB-231 breast carcinoma and dermal human fibroblasts (DHF). Some compounds displayed inhibition at μM IC50 values.
