1192322-79-4Relevant articles and documents
Design, synthesis and structure-activity relationship studies of novel 4 (1-adamantyl) phenyl analogues as hif-1α inhibitors
Xia, Yan,Duan, Qiong,Zhao, Bao-Hua,Li, Dong-Feng,Hou, Rui-Bin
, p. 338 - 346 (2016)
Hypoxia inducible factor-1 (HIF-1) is a key mediator during cancer cells to adapt tumor hypoxic condition. In this study, a series of adamantane-based compounds were synthesized and evaluated as potential inhibitors of HIF-1α. Examination of their structu