1192350-63-2

Upstream product

• 187324-66-9 (1R,2S)-2-(N-benzyl-N-mesitylenesulfonyl)amino-1-phenyl-1-propyl propionate 
• 1192350-59-6 (2R,4S,5R)-5-allyl-2-(4-methoxyphenyl)-4-methyl-1,3-dioxane 
• 1192350-60-9 (S)-2-((R)-1-(4-methoxybenzyloxy)ethyl)pent-4-en-1-ol 
• 1192350-61-0 1-methoxy-4-(((2S,3S)-3-methylhex-5-en-2-yloxy)methyl)benzene 

Downstream Products

• 1192350-64-3 (2R,3R,5S,6S)-((1R,2S)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 6-(4-methoxybenzyloxy)-2,5-dimethyl-3-(triethylsilyloxy)heptanoate 
• 1192350-72-3 (5S,10R,14S,15R,E)-5-allyl-3,3,17,17-tetraethyl-15-((2S,3S)-3-(4-methoxybenzyloxy)-2-methylbutyl)-10,14-dimethyl-7-methylene-10-(triethylsilyloxy)-4,16-dioxa-3,17-disilanonadec-11-en-9-yl acetate 
• 1192350-56-3 (2R,6S,7R,9S,10S,E)-2-((2S,6S)-6-allyl-2-hydroxy-4-methylenetetrahydro-2H-pyran-2-yl)-10-(4-methoxybenzyloxy)-6,9-dimethylundec-3-ene-2,7-diol 
• 1192350-65-4 (2S,3R,5S,6S)-6-(4-methoxybenzyloxy)-2,5-dimethyl-3-(triethylsilyloxy)heptyl 4-methylbenzenesulfonate 
• 1192350-58-5 triethyl((2R,3R,5S,6S)-1-iodo-6-(4-methoxybenzyloxy)-2,5-dimethylheptan-3-yloxy)silane 
• 1234064-57-3 C₅₆H₉₈O₇Si₃ 
• 1234064-59-5 C₅₀H₈₄O₇Si₂ 
• 1334289-25-6 C₄₈H₉₀O₆Si₃ 

Relevant academic research and scientific papers

Total synthesis of the proposed structure of iriomoteolide-1a

Full details of the total synthesis of the proposed structure of iriomoteolide-1a (1) are described. The key steps include (i) a Sakurai reaction between allylsilane 11 and aldehyde 10 that bears both a tertiary chiral center and vinyl iodide moiety (ii)

Asymmetric synthesis of the C(7)-C(23) fragment of lriomoteolide-1a

An efficient synthesis of the C(7)-C(23) fragment 2 of iriomoteolide-1a (1) has been accomplished via a S-alkyl Suzuki-Miyaura crosscoupling reaction followed by deprotection and cyclization to form the cyclic hemiketal core.