1192372-40-9

Basic information

• Product Name: 3-(2-chlorophenyl)-5-(4-fluorophenyl)-2-methyl-1H-pyrrole
• Synonyms: 3-(2-chlorophenyl)-5-(4-fluorophenyl)-2-methyl-1H-pyrrole
• CAS NO: 1192372-40-9
• Molecular Weight: 285.748
• Mol File: 1192372-40-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(2-chlorophenyl)-5-(4-fluorophenyl)-2-methyl-1H-pyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-chlorophenyl)-5-(4-fluorophenyl)-2-methyl-1H-pyrrole(1192372-40-9)
• EPA Substance Registry System: 3-(2-chlorophenyl)-5-(4-fluorophenyl)-2-methyl-1H-pyrrole(1192372-40-9)

Safety Data

• Hazardous Substances Data: 1192372-40-9(Hazardous Substances Data)

Upstream product

• 28081-11-0 3-(2-chlorophenyl)-1-(4-fluorophenyl)prop-2-en-1-one 
• 72187-91-8 α-amino propionitrile hydrochloride 

Relevant articles and documents

Cyclocondensation of α-aminonitriles and enones: A short access to 3,4-dihydro-2H-pyrrole 2-carbonitriles and 2,3,5-trisubstituted pyrroles

(Chemical Equation Presented) The reaction of α,β-unsaturated carbonyl compounds with aminoacetonitrile hydrochloride furnishes 3,5-disubstituted 3,4-dihydro-2H-pyrrole-2-carbonitriles in a one-pot reaction sequence. While these products can serve as starting materials for the preparation of polysubstituted pyrrolizidines, they are kinetically stable against the base-induced elimination of HCN. In contrast, their 2-substituted analogues obtained from α-substituted α-aminonitriles can be readily converted to the corresponding 2,3,5-trisubstituted pyrroles under microwave irradiation. The key step presumably involves the thermal electrocyclization of a stabilized 2-azapentadienyl anion formed by condensation of the reactants and subsequent deprotonation.