72187-91-8

Upstream product

• 75-07-0 acetaldehyde 
• 51806-98-5 2-aminopropanenitrile 
• 151-50-8 potassium cyanide 

Downstream Products

• 1462363-72-9 3-(1-cyanoethyl)-1-methyl-1-phenylurea 
• 1462363-82-1 1-(4-chlorophenyl)-3-(1-cyanoethyl)-1-methylurea 
• 1462364-10-8 3-(1-cyanoethyl)-1-(3-fluorophenyl)-1-methylurea 
• 1462364-33-5 3-(1-cyanoethyl)-1-(2-methoxyphenyl)-1-methylurea 
• 1462364-65-3 3-(1-cyanoethyl)-1-methyl-1-[4-(trifluoromethyl)phenyl]urea 
• 1462364-85-7 1-(3-chlorophenyl)-3-(1-cyanoethyl)-1-methylurea 
• 19861-71-3 N-(1-cyanoethyl)acetamide 
• 64608-69-1 2-(1H-pyrrol-1-yl)propanenitrile 
• 1262845-88-4 3-{5-[3-chloro-4-(4-methylpiperazin-1-yl)phenyl]isoxazol-3-yl}-N-(cyano-methyl-methyl)benzamide 
• 1262845-85-1 (6-{4-[3-(3-{3-[(cyano-methyl-methyl)carbamoyl]phenyl}isoxazol-5-yl)phenyl]piperazin-1-yl}hexyl)carbamic acid tert-butyl ester 
• 1192372-39-6 5-(4-fluorophenyl)-3-(4-methoxyphenyl)-2-methyl-1H-pyrrole 
• 1192372-38-5 5-(4-chlorophenyl)-2-methyl-3-(3-nitrophenyl)-1H-pyrrole 
• 1192372-40-9 3-(2-chlorophenyl)-5-(4-fluorophenyl)-2-methyl-1H-pyrrole 
• 78-90-0 1,2-diaminopropan 

Relevant academic research and scientific papers

Prebiotically Plausible Organocatalysts Enabling a Selective Photoredox α-Alkylation of Aldehydes on the Early Earth

Organocatalysis is a powerful approach to extend and (enantio-) selectively modify molecular structures. Adapting this concept to the Early Earth scenario offers a promising solution to explain their evolution into a complex homochiral world. Herein, we present a class of imidazolidine-4-thione organocatalysts, easily accessible from simple molecules available on an Early Earth under highly plausible prebiotic reaction conditions. These imidazolidine-4-thiones are readily formed from mixtures of aldehydes or ketones in presence of ammonia, cyanides and hydrogen sulfide in high selectivity and distinct preference for individual compounds of the resulting catalyst library. These organocatalysts enable the enantioselective α-alkylation of aldehydes under prebiotic conditions and show activities that correlate with the selectivity of their formation. Furthermore, the crystallization of single catalysts as conglomerates opens the pathway for symmetry breaking.

Intramolecular arylation of amino acid enolates

Dianionic enolates formed from N′-aryl urea derivatives of amino acids undergo intramolecular C-arylation by attack of the enolate anion on the N′-aryl ring, leading to a hydantoin derivative of a quaternary amino acid. In situ IR studies allow identification of four intermediates on the reaction pathway.

Regioselective synthesis of DTPA derivatives

The present invention provides a process for high yield regioselective synthesis of DTPA derivatives that eliminates the need for ion exchange chromotographic separation of intermediates. Moreover, as this process yields a single regioisomer of the chelat

Preparation of α-aminothioamides from aldehydes

The conversion of aldehydes into α-aminonitriles and thence into imidazolidin-4-thiones has been studied.Hydrolysis of the appropriate imidazolidin-4-thiones gave thioamides of nine naturally occuring α-amino acids.The possible pre-biotic significance of these compounds is discussed.