119238-07-2

Upstream product

• 88911-34-6 5-[(3aR,5S,6S,6aR)-5-Hydroxy-6-((E)-(R)-3-hydroxy-oct-1-enyl)-1,3a,4,5,6,6a-hexahydro-pentalen-2-yl]-pentanoic acid methyl ester 
• 88931-51-5 isocarbacyclin 
• 36969-89-8 dimethyl 2-oxoheptylphosphonate 
• 65025-95-8 (3aR,4S,5R,6aS)-4-({[dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl)-5-(tetrahydro-2H-pyran-2-yloxy)hexahydro-2H-cyclopenta[b]furan-2-one 
• 95205-48-4 (1R^*,5S^*,6R^*,7R^*)-3-acetoxymethyl-7-tert-butyldimethylsilyloxy-6-(3-tert-butyldimethylsilyloxy-(E)-1-octenyl)bicyclo<3.3.0>oct-2-ene 
• 125089-83-0 (1R^*,5S^*,6R^*,7R^*)-7-tert-butyldimethylsilyloxy-6-(3-tert-butyldimethylsilyloxy-(E)-1-octenyl)bicyclo<3.3.0>oct-2-ene-3-pentanal 
• 95205-50-8 (1R^*,5S^*,6R^*,7R^*)-7-tert-butyldimethylsilyloxy-6-(3-tert-butyldimethylsilyloxy-(E)-1-octenyl)-3-(5-hydroxypentyl)bicyclo<3.3.0>oct-2-ene 
• 95205-46-2 (1R^*,5S^*,6R^*,7R^*)-7-tert-butyldimethylsilyloxy-6-(3-tert-butyldimethylsilyloxy-(E)-1-octenyl)-3-hydroxymethylbicyclo<3.3.0>oct-2-ene 
• 95205-42-8 (1R^*,5S^*,6R^*,7R^*)-7-tert-butyldimethylsilyloxy-6-(3-tert-butyldimethylsilyloxy-(E)-1-octenyl)bicyclo<3.3.0>oct-2-ene-3-carbaldehyde 
• 95205-54-2 (1S^*,2S^*,3S^*,4R^*)-4-tert-butyldimethylsilyloxy-3-(3-tert-butyldimethylsilyloxy-(E)-1-octenyl)-1-hydroxymethyl-2-(3-hydroxypropyl)-cyclopentane 
• 82304-78-7 (2S,3S,4S)-2-Allyl-4-(tert-butyl-dimethyl-silanyloxy)-3-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-cyclopentanone 
• 95205-53-1 (2R^*,3S^*,4R^*)-2-allyl-4-tert-butyldimethylsilyloxy-3-(3-tert-butyldimethylsilyloxy-(E)-1-octenyl)-1-methylenecyclopentane 
• 95205-45-1 (1R^*,5S^*,6R^*,7R^*)-7-tert-butyldimethylsilyloxy-6-(3-tert-butyldimethylsilyloxy-(E)-1-octenyl)bicyclo<3.3.0>oct-2-ene-3-pentanoic acid 
• 91078-20-5 (E)-5-[(3aS,4S,5R,6aS)-5-(tert-Butyl-dimethyl-silanyloxy)-4-(tert-butyl-dimethyl-silanyloxymethyl)-1-hydroxy-octahydro-pentalen-2-yl]-pent-4-enoic acid methyl ester 

Relevant academic research and scientific papers

THE INTRAMOLECULAR THERMAL ENE REACTION ROUTE TO (+)-9(O)-METHANO-Δ6(9α)-PGI1

(+)-9(O)-Methano-Δ6(9α)-PGI1, a more potent carbon analog than carbacyclin, has been synthesized from the Corey lactone by utilizing the intramolecular thermal ene reaction as a key step.

PRACTICAL SYNTHESIS OF (+)-9(O)-METHANO-Δ6(9α)-PGI1. THE HIGHLY POTENT CARBON ANALOG OF PROSTACYCLIN

A practical synthesis of (+)-9(O)-methano-Δ6(9α)-PGI1, potentially a useful therapeutic agent, has been accomplished by utilizing the intramolecular aldol condensation as key step followed by the Wittig reaction and the regioselective hydrogenation.

AN EFFICIENT SYNTHESIS OF ISOCARBACYCLIN STARTING FROM FURFURAL

Two synthetic routes to isocarbacyclin starting from furfural are described.One route involves the regioselective hydrogenation of the disubstituted olefin in the presence of two other olefinic double bonds, and the other includes the highly regioselective organocopper coupling with the allylic electrophile as a key step.

REGIOCONTROLLED CONVERSION OF α,α-UNSATURATED KETONES TO OLEFINS VIA ALLYLSILANES: SYNTHESIS OF dl-9(O)-METHANO-Δ6(9α)-PGI1

A synthesis of dl-9(O)-methano-Δ6(9α)-PGI1 (1), a more potent prostacyclin analog than carbacyclin, has been accomplished utilizing regiocontrolled transformation of the enone to the olefin via the allylsilane as a key step.