119245-13-5Relevant articles and documents
l-HYDROXYCYCLOALKANECARBOXAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS
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Page/Page column 27-28, (2008/06/13)
α-Hydroxycycloalkanecarboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof, wherein formula (a) is a single or double bond; Rl, R2 and R3 are each independently selected from H, halogen and OH; or Rl and R2 attached to the same carbon atom together represent oxo; R4 is H or methyl; R5 is Cl or F; R6 is selected from -CO2-C1-4alkyl, -O-C1-4alkyl, -O- C1-4haloalkyl, 2-methyltetrazol-5-yl, 5-methyl l,2,4-oxadiazol-3-yl, 3-methyl-1,2,4-oxadiazol-5-yl, 5-halomethyl-l,2,4-oxadiazol-3-yl, 3-halomethyl- l,2,4-oxadiazol-5-yl, tetrazol-5-yl, 5-halomethyl-l,2,3-triazolyl, and 5-methyl-l ,2,3-triazolyl; R7 and R8 are each independently Cl or F; and n is 0 or 1, are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway.
Ring Expansions of Photoadducts. Potential Applications in the Synthesis of Triquinane and Taxane Skeletons
Lange, Gordon L.,Decicco, Carl P.,Willson, Jennifer,Strickland, Lou Anne
, p. 1805 - 1810 (2007/10/02)
Photoadditions of enones 4 or 18 with cyclopentene gave in good yield adducts 5/6 or 20/21, respectively, with the anti isomers predominating by a ratio of ca. 9:1.These adducts were converted to hydroxy ketones 9 or 24 by the following sequence: ketalization, LiAlH4 reduction, and hydrolysis.The alcohol function in these ketones was converted to a good leaving group, and the resultant derivatives were solvolyzed to give ring-expanded products 12 or 28 as well as bridged products 13-14 or 29-32, respectively.The sequence starting with the enone 18 has potentialapplications in the synthesis of the triquinane and the taxol carbon skeletons.
