1192479-36-9

Basic information

• Product Name: 2-chloro-5-fluoro-4,6-dimethylpyrimidine
• Synonyms: 2-chloro-5-fluoro-4,6-dimethylpyrimidine
• CAS NO: 1192479-36-9
• Molecular Weight: 160.578
• Mol File: 1192479-36-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-chloro-5-fluoro-4,6-dimethylpyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-5-fluoro-4,6-dimethylpyrimidine(1192479-36-9)
• EPA Substance Registry System: 2-chloro-5-fluoro-4,6-dimethylpyrimidine(1192479-36-9)

Safety Data

• Hazardous Substances Data: 1192479-36-9(Hazardous Substances Data)

Usage

Description

2-chloro-5-fluoro-4,6-dimethylpyrimidine is a pyrimidine derivative with the chemical formula C6H6ClFN2. It is a white solid and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 2-chloro-5-fluoro-4,6-dimethylpyrimidine is known for its versatile reactivity and unique chemical properties, making it an important building block in organic synthesis and drug development.

Uses

Used in Pharmaceutical Industry:
2-chloro-5-fluoro-4,6-dimethylpyrimidine is used as an intermediate in the synthesis of various drugs. Its versatile reactivity allows for the production of a wide range of pharmaceutical compounds, contributing to the development of new medications.
Used in Agrochemical Industry:
2-chloro-5-fluoro-4,6-dimethylpyrimidine is also used as an intermediate in the synthesis of agrochemicals, specifically in the production of crop protection products. Its unique chemical properties enable the creation of effective solutions for agricultural applications.

Upstream product

• 767-80-6 5-fluoropyrimidine-2,4,6-triol 
• 75-16-1 methylmagnesium bromide 
• 954220-98-5 2,4-dichloro-5-fluoro-6-methyl-pyrimidine 

Relevant articles and documents

Overcoming Time-Dependent Inhibition (TDI) of Cytochrome P450 3A4 (CYP3A4) Resulting from Bioactivation of a Fluoropyrimidine Moiety

Herein we describe structure-activity relationship (SAR) and metabolite identification (Met-ID) studies that provided insight into the origin of time-dependent inhibition (TDI) of cytochrome P450 3A4 (CYP3A4) by compound 1. Collectively, these efforts revealed that bioactivation of the fluoropyrimidine moiety of 1 led to reactive metabolite formation via oxidative defluorination and was responsible for the observed TDI. We discovered that substitution at both the 4- and 6-positions of the 5-fluoropyrimidine of 1 was necessary to ameliorate this TDI as exemplified by compound 19.

DISUBSTITUTED OCTAHY-DROPYRROLO [3,4-C] PYRROLES AS OREXIN RECEPTOR MODULATORS

Disubstituted octahydropyrrolo[3,4-c]pyrrole compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.

FUSED HETEROCYCLIC COMPOUNDS AS OREXIN RECEPTOR MODULATORS

Certain disubstituted 3,8-diaza-bicyclo[4.2.0]octane and 3,6-diazabicyclo [3.2.0]heptane are described, which are useful as orexin inhibitors. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.