1192479-39-2

Upstream product

• 67-56-1 methanol 
• 79757-77-0 (4-bromothiophen-2-yl)methanol 
• 917772-59-9 C₈H₅BrO₄S 
• 917772-58-8 C₈H₃BrO₃S 
• 160005-43-6 2-(4-bromothiophen-2-yl)acetonitrile 
• 170859-70-8 4-bromo-2-(chloromethyl)thiophene 
• 18791-75-8 4-Bromothiophen-2-aldehyde 
• 917772-60-2 C₁₇H₁₆BrNO₄S 

Downstream Products

• 917772-62-4 C₂₃H₃₁BrN₂O₄SSi 
• 1192479-41-6 C₂₃H₂₇BrN₄O₃S 

Relevant academic research and scientific papers

THIOPHENYL-SUBSTITUTED 2-IMINO-3-METHYL PYRROLO PYRIMIDINONE COMPOUNDS AS BACE-1 INHIBITORS, COMPOSITIONS, AND THEIR USE

In its many embodiments, the present invention provides provides certain thiophenyl-substituted 2-imino-3-methyl pyrrolo pyrimidone compounds, including compounds (or tautomers or a pharmaceutically acceptable salts thereof) having the structural Formula (III): wherein R2, R3, R4, R5, R6, R7, R8, and R9 are each selected independently and as defined herein. Pharmaceutical compositions comprising one or more such compounds, and methods for their preparation and use in treating pathologies associated with amyloid beta (Aβ) protein, including Alzheimer's Disease, are also disclosed.

ASPARTYL PROTEASE INHIBITORS

Disclosed are compounds of the formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein j, k, U, W, R, R1, R2, R3, R4, R6, R7 and R7a are as described above in the specification. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula (I) in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.