1192486-00-2

Basic information

• Product Name: 2-[1-(4-fluorobenzoyl)-1H-indol-3-yl]-2-oxo-N-(pyridin-4-yl)acetamide
• CAS NO: 1192486-00-2
• Molecular Weight: 387.37
• Mol File: 1192486-00-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[1-(4-fluorobenzoyl)-1H-indol-3-yl]-2-oxo-N-(pyridin-4-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[1-(4-fluorobenzoyl)-1H-indol-3-yl]-2-oxo-N-(pyridin-4-yl)acetamide(1192486-00-2)
• EPA Substance Registry System: 2-[1-(4-fluorobenzoyl)-1H-indol-3-yl]-2-oxo-N-(pyridin-4-yl)acetamide(1192486-00-2)

Safety Data

• Hazardous Substances Data: 1192486-00-2(Hazardous Substances Data)

Upstream product

• 204206-04-2 2-(1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide 
• 403-43-0 4-fluorobenzoyl chloride 

Relevant articles and documents

Synthesis and structure-activity relationships of N-aryl(indol-3-yl)glyoxamides as antitumor agents

The synthesis and study of the structure-activity relationships of cytotoxic compounds based on N-pyridinyl or N-aryl-2-(1-benzylindol-3-yl)glyoxamide skeleton, represented by the lead structures D-24241 and D-24851, are described. The presence of N-(pyridin-4-yl) moiety was crucial for activity and 2-[1-(4-chloro-3-nitrobenzyl)-1H-indol-3-yl]-2-oxo-N-(pyridin-4-yl)aceta mide (55), the most potent derivative, showed IC50 = 39 nM, 51 nM and 11 nM against HeLa/KB (human cervix carcinoma), L1210 (murine leukemia) and SKOV3 (human ovarian carcinoma) cell lines proliferation assay, respectively, as active as the lead compounds.