1192569-38-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-5-quinolinecarboxylic acid methyl ester is used as a precursor in the synthesis of antimalarial drugs, leveraging its structural similarity to chloroquine for the development of new medications with improved efficacy and reduced side effects.
Used in Anti-inflammatory Applications:
2-Chloro-5-quinolinecarboxylic acid methyl ester is utilized as an anti-inflammatory agent, potentially mitigating inflammation through its effects on immune response modulation, making it a candidate for treating conditions characterized by excessive inflammation.
Used in Antiviral Applications:
2-Chloro-5-quinolinecarboxylic acid methyl ester is employed as an antiviral agent, potentially inhibiting viral replication and reducing the severity of viral infections, offering a therapeutic option for viral diseases.
Used in Cancer Treatment:
2-Chloro-5-quinolinecarboxylic acid methyl ester is used as a potential cancer treatment, with research indicating that it may have the ability to target and kill cancer cells, offering a novel approach to cancer therapy.
Used in Autoimmune Disease Therapy:
2-Chloro-5-quinolinecarboxylic acid methyl ester is used as a therapeutic tool for autoimmune diseases, potentially modulating the immune system to reduce the impact of conditions where the immune system mistakenly attacks the body's own tissues.

Upstream product

• 4964-71-0 5-bromoquinoline 
• 70758-29-1 5-(Methoxycarbonyl)quinoline-1-oxide 
• 16675-62-0 methyl quinoline-5-carboxylate 
• 70758-34-8 2-oxy-quinoline-5-carboxylic acid methyl ester 
• 1092287-30-3 2-chloroquinoline-5-carboxylic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 1192569-53-1 2-Chloroquinoline-5-carbonyl chloride 

Relevant academic research and scientific papers

INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS

Provided herein are compounds of formula (V) that bind to BF3 of an androgen receptor (AR), which can modulate the AR for the treatment of Kennedy's disease.

Inhibitory phosphodiesterase 4-contained compound and preparation and medical application methods thereof

The invention relates to the field of medicinal chemistry, particularly to an inhibitory phosphodiesterase 4-contained micro-molecular compound (I), a preparation method of the inhibitory phosphodiesterase 4-contained micro-molecular compound (I) and a pharmaceutical composition containing the inhibitory phosphodiesterase 4-contained micro-molecular compound (I). pharmacodynamics experiments provethat the inhibitory phosphodiesterase 4-contained micro-molecular compound (I) achieves the activity inhibiting and inflammation treating effects of PDE-4 (phosphodiesterase 4).

BENZOTHIOPHENE DERIVATIVE

[Problem to be Solved] It is intended to provide a compound having PDE10A inhibitory activity and having a novel structure, or an isotope thereof or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an active ingredient. [Solution] The present invention provides a compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof.

COMPOSITIONS AND METHODS FOR MODULATING FXR

The present invention relates to compounds of Formula (I), a stereoisomer, enantiomer, a pharmaceutically acceptable salt or an amino acid conjugate thereof; wherein variables are as defined herein; and their pharmaceutical compositions, which are useful as modulators of the activity of Farnesiod X receptors (FXR).

QUINOLINE OR ISOQUINOLINE SUBSTITUTED P2X7 ANTAGONISTS

The present invention is related to novel compounds of formula (I) having P2X7 antagonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment or prophylaxis of diseases associated with P2X7 receptor activity in animals, in particular humans. (I)