70758-34-8

Usage

Uses

Used in Pharmaceutical Industry:
5-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, methyl ester is used as an intermediate in the synthesis of anti-tumor and anti-inflammatory drugs. Its unique chemical structure allows for the development of medications that target specific biological pathways, offering potential therapeutic benefits in the treatment of various diseases.
Used in Agrochemical Industry:
5-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, methyl ester is also utilized as an intermediate in the production of agrochemicals, contributing to the development of effective pesticides and other agricultural products that protect crops and enhance agricultural productivity.
Used in Dye and Pigment Manufacturing:
5-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, methyl ester is used in the manufacturing of dyes and pigments, providing a range of colors and properties for various applications in the textile, paint, and plastics industries.
Used in Flavoring and Fragrance Industry:
Additionally, 5-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, methyl ester is employed in the preparation of flavoring agents and fragrance chemicals, adding unique scents and tastes to various consumer products.
Safety Precautions:
It is important to handle 5-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, methyl ester with caution, as it may be harmful if ingested or inhaled and can cause skin and eye irritation upon contact. Proper safety measures should be taken during its production, storage, and use to minimize potential health risks.

Upstream product

• 99-05-8 meta-aminobenzoic acid 
• 88371-31-7 C₁₃H₁₅NO₄ 
• 4518-10-9 Methyl 3-aminobenzoate 
• 83734-43-4 1,2-dihydro-2-oxo-5-quinolinecarboxylic acid 
• 83734-42-3 3-(3-ethoxyacryloylamino)benzoic acid 
• 67-56-1 methanol 

Downstream Products

• 90098-47-8 2-(4-Chloro-benzoylamino)-3-(2-oxo-1,2-dihydro-quinolin-5-yl)-propionic acid 
• 1192569-53-1 2-Chloroquinoline-5-carbonyl chloride 
• 1192569-38-2 Methyl 2-chloroquinoline-5-carboxylate 

Relevant academic research and scientific papers

ANTI-ANGIOGENESIS COMPOUND, INTERMEDIATE AND USE THEREOF

Disclosed are an anti-abnormal proliferation of angiogenesis compound represented by formula I, use and intermediate thereof. The compound has good effect against abnormal proliferation of angiogenesis, and the activity of the compound is produced by inhibiting VEGFR2. The compound can be used for treating diseases, such as wet macular degeneration, inflammation, malignant tumor and the like, caused by abnormity of angiogenesis and protein kinases such as VEGFR2, FGFR2 and the like.

ANTI-ANGIOGENESIS COMPOUND, INTERMEDIATE AND USE THEREOF

Disclosed are an anti-abnormal proliferation of angiogenesis compound represented by formula I, use and intermediate thereof. The compound has good effect against abnormal proliferation of angiogenesis, and the activity of the compound is produced by inhibiting VEGFR2. The compound can be used for treating diseases, such as wet macular degeneration, inflammation, malignant tumor and the like, caused by abnormity of angiogenesis and protein kinases such as VEGFR2, FGFR2 and the like.

Synthesis and molecular modeling study of new trimeric quinoline derivatives

Di- and trimeric quinoline derivatives have been recently described as potential modulators of Bcl-2 family protein interactions. However, only a few trimeric compounds have been described so far and an enlargement of the number of analogs of this class is needed to expand the structure-activity relationship study. Therefore, the synthesis of six new trimeric quinoline derivatives is reported. Moreover molecular modeling experiments were performed to study the conformational arrangement of compound 36 in Bak binding site of Bcl-x L, showing that these compounds could be potential ligands for Bcl-xL.

Synthesis and biological activities of new di-and trimeric quinoline derivatives

The synthesis of non-peptidic helix mimetics based on a trimeric quinoline scaffold is described. The ability of these new compounds, as well as their synthetic dimeric intermediates, to bind to various members of the Bcl-2 protein anti-apoptotic group is also evaluated. The most interesting derivative of this new series (compound A) inhibited Bcl-xL/Bak, Bcl-xL/Bax and Bcl-xL/Bid interactions with IC50 values around 25 μM.

Carbostyril derivatives

Disclosed are carbostyril derivatives and their salts of the formulas STR1 The compounds have anti-peptic ulcer effects, and are useful as a treating agent for curing peptic ulcers in the digestive system, such as ulcers in the stomach and in the duodenum. The compounds particularly have prophylaxis and curing effects for treating chronic ulcers, for example experimental acetic acid-induced ulcers and cautery ulcers, with both low toxicity and few side-effects. Also disclosed are processes for preparing the compounds and for preparing pharmaceutical compositions containing them.