70758-34-8

Basic information

• Product Name: 5-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, Methyl ester
• Synonyms: 5-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, Methyl ester;Methyl 2-oxo-1,2-dihydroquinoline-5-carboxylate
• CAS NO: 70758-34-8
• Molecular Formula: C₁₁H₉NO₃
• Molecular Weight: 203.19406
• Mol File: 70758-34-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 251-254 °C(Solv: methanol (67-56-1))
• Boiling Point: 431.3±45.0 °C(Predicted)
• Appearance: /
• Density: 1.270±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 11.20±0.70(Predicted)
• CAS DataBase Reference: 5-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, Methyl ester(70758-34-8)
• EPA Substance Registry System: 5-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, Methyl ester(70758-34-8)

Safety Data

• Hazardous Substances Data: 70758-34-8(Hazardous Substances Data)

Usage

General Description

5-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, methyl ester, also known as Methyl quinaldine-3-carboxylate, is a chemical compound with the molecular formula C11H9NO3. It is a derivative of quinoline and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Methyl quinaldine-3-carboxylate is a yellow-brown crystalline powder with a melting point of 84-88°C and is soluble in organic solvents. It is primarily used in the production of anti-tumor and anti-inflammatory drugs, as well as in the manufacturing of dyes and pigments. Additionally, it is utilized in the preparation of flavoring agents and fragrance chemicals. However, it is important to handle this compound with caution, as it may be harmful if ingested or inhaled and can cause skin and eye irritation upon contact.

Upstream product

• 4518-10-9 Methyl 3-aminobenzoate 
• 88371-31-7 C₁₃H₁₅NO₄ 
• 99-05-8 meta-aminobenzoic acid 
• 83734-43-4 1,2-dihydro-2-oxo-5-quinolinecarboxylic acid 
• 83734-42-3 3-(3-ethoxyacryloylamino)benzoic acid 
• 67-56-1 methanol 

Downstream Products

• 90098-47-8 2-(4-Chloro-benzoylamino)-3-(2-oxo-1,2-dihydro-quinolin-5-yl)-propionic acid 
• 1192569-53-1 2-Chloroquinoline-5-carbonyl chloride 
• 1192569-38-2 Methyl 2-chloroquinoline-5-carboxylate 

Relevant articles and documents

ANTI-ANGIOGENESIS COMPOUND, INTERMEDIATE AND USE THEREOF

Disclosed are an anti-abnormal proliferation of angiogenesis compound represented by formula I, use and intermediate thereof. The compound has good effect against abnormal proliferation of angiogenesis, and the activity of the compound is produced by inhibiting VEGFR2. The compound can be used for treating diseases, such as wet macular degeneration, inflammation, malignant tumor and the like, caused by abnormity of angiogenesis and protein kinases such as VEGFR2, FGFR2 and the like.

Synthesis and molecular modeling study of new trimeric quinoline derivatives

Di- and trimeric quinoline derivatives have been recently described as potential modulators of Bcl-2 family protein interactions. However, only a few trimeric compounds have been described so far and an enlargement of the number of analogs of this class is needed to expand the structure-activity relationship study. Therefore, the synthesis of six new trimeric quinoline derivatives is reported. Moreover molecular modeling experiments were performed to study the conformational arrangement of compound 36 in Bak binding site of Bcl-x L, showing that these compounds could be potential ligands for Bcl-xL.

Carbostyril derivatives

Disclosed are carbostyril derivatives and their salts of the formulas STR1 The compounds have anti-peptic ulcer effects, and are useful as a treating agent for curing peptic ulcers in the digestive system, such as ulcers in the stomach and in the duodenum. The compounds particularly have prophylaxis and curing effects for treating chronic ulcers, for example experimental acetic acid-induced ulcers and cautery ulcers, with both low toxicity and few side-effects. Also disclosed are processes for preparing the compounds and for preparing pharmaceutical compositions containing them.