119271-18-0Relevant academic research and scientific papers
N-Arylsulfonyl-N'-(pyrimidin-4-yl)ureas-Synthesis and Reaction with Dimethyl Sulfoxide
Zeuner, F.,Niclas, H.-J.
, p. 121 - 128 (2007/10/02)
The N-arylsulfonyl-N'-(pyrimidin-4-yl)ureas (3a-l) were synthesized by reaction of arylsulfonyl isocyanates (1) with 4-amino-2,6-dialkylpyrimidines (2).Treatment of 3 with alkali or of 1 with an excess of 4-amino-2,6-dimethylpyrimidine (2a) gave the salts 4a-e.Reaction of the ureas 3a-c with dimethyl sulfoxide at 90 to 120 deg C afforded N,N'-bis(2,6-dimethylpyrimidin-4-yl) ureas 8a-c.The reaction is assumed to involve a four-centre mechanism with 5 as intermediate.
