119292-64-7

Upstream product

• 1131-47-1 2,4-dimethyl-6,7-benzo-1,5-diazepine 
• 95-54-5 1,2-diamino-benzene 
• 123-54-6 acetylacetone 

Downstream Products

• 217185-06-3 N,N'-di(p-nitrobenzoyl)-2,4-dimethyl-2,3,4,5-terahydro-1H-1,5-benzodiazepine 
• 1393093-31-6 5-N-Ts-2,4-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine 
• 217185-07-4 N,N'-di(p-aminobenzoyl)-2,4-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine 

Relevant academic research and scientific papers

Enantioselective synthesis of tunable chiral pyridine-aminophosphine ligands and their applications in asymmetric hydrogenation

A small library of tunable chiral pyridine-aminophosphine ligands were enantioselectively synthesized based on chiral 2-(pyridin-2-yl)-substituted 1,2,3,4-tetrahydroquinoline scaffolds, which were obtained in high yields and with excellent enantioselectivities via ruthenium-catalyzed asymmetric hydrogenation of 2-(pyridin-2-yl)quinolines. The protocol features a wide substrate scope and mild reaction conditions, enabling scalable synthesis. These chiral P,N ligands were successfully applied in the Ir-catalyzed asymmetric hydrogenation of benchmark olefins and challenging seven-membered cyclic imines including benzazepines and benzodiazepines. Excellent enantio- and diastereoselectivity (up to 99% ee and >20:1 dr), and/or unprecedented chemoselectivity were obtained in the asymmetric hydrogenation of 2,4-diaryl-3H-benzo[b]azepines and 2,4-diaryl-3H-benzo[b][1,4]diazepines.

Tetrahydroquinoline skeleton chiral phosphine-nitrogen ligand and preparation method and application thereof

The invention relates to the field of asymmetric catalytic hydrogenation, in particular to a tetrahydroquinoline skeleton chiral phosphine-nitrogen ligand and a preparation method and application thereof. The tetrahydroquinoline skeleton chiral phosphine-