1131-47-1Relevant articles and documents
Ultrasound enhanced synthesis of 1,5-benzodiazepinic heterocyclic rings
Guzen, Karla P.,Cella, Rodrigo,Stefani, Hélio A.
, p. 8133 - 8136 (2006)
1,5-Benzodiazepines are synthesized by a reaction of o-phenylenediamines with a diketone or ketones series by ultrasound irradiation in presence of APTS. The condensation occurred in a mild condition with good to excellent yields.
An efficient synthesis of 3H-1,5-benzodiazepine derivatives catalyzed by heteropolyacids as a heterogeneous recyclable catalyst
Heravi, Majid M.,Sadjadi, Samaheh,Oskooie, Hossein A.,Hekmatshoar, Rahim,Bamoharram, Fatemeh F.
, p. 842 - 845 (2008)
3H-1,5-benzodiazepines were synthesized by the condensation of o-phenylendiamine and various 1,3-diketones in the presence of various heteropolyacid (HPA) catalysts under mild conditions in very good yields and with high selectivity.
Enantioselective synthesis of tunable chiral pyridine-aminophosphine ligands and their applications in asymmetric hydrogenation
Liu, Youran,Chen, Fei,He, Yan-Mei,Li, Chenghao,Fan, Qing-Hua
supporting information, p. 5099 - 5105 (2019/05/29)
A small library of tunable chiral pyridine-aminophosphine ligands were enantioselectively synthesized based on chiral 2-(pyridin-2-yl)-substituted 1,2,3,4-tetrahydroquinoline scaffolds, which were obtained in high yields and with excellent enantioselectivities via ruthenium-catalyzed asymmetric hydrogenation of 2-(pyridin-2-yl)quinolines. The protocol features a wide substrate scope and mild reaction conditions, enabling scalable synthesis. These chiral P,N ligands were successfully applied in the Ir-catalyzed asymmetric hydrogenation of benchmark olefins and challenging seven-membered cyclic imines including benzazepines and benzodiazepines. Excellent enantio- and diastereoselectivity (up to 99% ee and >20:1 dr), and/or unprecedented chemoselectivity were obtained in the asymmetric hydrogenation of 2,4-diaryl-3H-benzo[b]azepines and 2,4-diaryl-3H-benzo[b][1,4]diazepines.
Mixing with microwaves: Solvent-free and catalyst-free synthesis of pyrazoles and diazepines
Vaddula, Buchi Reddy,Varma, Rajender S.,Leazer, John
supporting information, p. 1538 - 1541 (2013/03/14)
A simple and facile condensation of hydrazines/hydrazides and diamines with 1,3-diketones/β-ketoester leads to the preparation of pyrazoles and diazepines in high yields. This eco-friendly protocol is accelerated by microwave heating and efficiently carried out without any reaction solvent or catalyst in as little as 5 min.
Zn[(l)proline]2 in water: A new easily accessible and recyclable catalytic system for the synthesis of pyrazoles
Kidwai, Mazaahir,Jain, Arti,Poddar, Roona
experimental part, p. 1939 - 1944 (2011/06/19)
Zn[(l)proline]2 has been found to be an efficient catalyst for the synthesis of pyrazole derivatives in pure water at room temperature. Reaction afforded moderate to excellent yield within a lesser time. Various pyrazoles which could not be prepared by other methods can be easily prepared by this method efficiently. Catalyst exhibits recyclability up to five runs. Hence our present protocol is economical and clean comprise of green reagent, solvent and catalyst.