1192931-76-2

Upstream product

• 37885-07-7 1-(2-amino-4-(trifluoromethyl)phenyl)ethanone 
• 1483-54-1 2-amino-4-trifluoromethylbenzonitrile 
• 873006-03-2 1-(2-iodo-4-trifluoromethylphenyl)ethanol 

Downstream Products

• 1192931-45-5 (E)-N-[1-(2-iodo-4-trifluoromethylphenyl)ethylidene]-4-methoxyaniline 
• 1225288-95-8 3,5,6-tris(4-chlorophenyl)-1,2,4-tris(trifluoromethyl)benzene 

Relevant academic research and scientific papers

One-Pot Synthesis of Spirocyclopenta[ a]indene Derivatives via a Cascade Ring Expansion and Intramolecular Friedel-Crafts-Type Cyclization

A one-pot efficient synthetic approach for the rapid construction of spirocyclopenta[a]indene derivatives has been developed via an iodine-initiated cascade ring expansion and intramolecular Friedel-Crafts-type cyclization from propargyl alcohol-tethered alkylidenecyclobutanes under mild conditions with broad substrate scope. This cascade process can be elegantly conducted on a gram scale. A plausible reaction mechanism has been proposed on the basis of a series of deuterium labeling and control experiments.