37885-07-7

Basic information

• Product Name: Ethanone,1-[2-amino-4-(trifluoromethyl)phenyl]-
• Synonyms: 1-[2-Amino-4-(trifluoromethyl)phenyl]ethan-1-one, 2-Acetyl-5-(trifluoromethyl)aniline, 4-Acetyl-3-aminobenzotrifluoride;1-[2-amino-4-(trifluoromethyl)phenyl]ethan-1-one;Ethanone,1-[2-amino-4-(trifluoromethyl)phenyl]-;1-[2-aMino-4-(trifluoroMethyl)phenyl]-Ethanone;2'-Amino-4'-(trifluoromethyl)acetophenone
• CAS NO: 37885-07-7
• Molecular Formula: C₉H₈F₃NO
• Molecular Weight: 203.16
• Mol File: 37885-07-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 274℃
• Flash Point: 120℃
• Appearance: /
• Density: 1.296
• Vapor Pressure: 0.00554mmHg at 25°C
• Refractive Index: 1.492
• Storage Temp.: 2-8°C(protect from light)
• PKA: 1.08±0.10(Predicted)
• CAS DataBase Reference: Ethanone,1-[2-amino-4-(trifluoromethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone,1-[2-amino-4-(trifluoromethyl)phenyl]-(37885-07-7)
• EPA Substance Registry System: Ethanone,1-[2-amino-4-(trifluoromethyl)phenyl]-(37885-07-7)

Safety Data

• Hazardous Substances Data: 37885-07-7(Hazardous Substances Data)

Usage

General Description

"Ethanone,1-[2-amino-4-(trifluoromethyl)phenyl]-" is a chemical compound that belongs to the family of Ketones. The molecular formula of this compound is C9H8F3NO. This colorless, organic liquid presents distinct physical and chemical properties, including a significant molecular weight of about 215.16 g/mol. As the name suggests, it contains carbon (C), hydrogen (H), fluorine (F), nitrogen (N), and oxygen (O) in its molecular structure. This chemical is associated with broad applications in the field of chemical research, particularly in the development of pharmaceutical drugs, due to its amino and trifluoromethyl groups. However, like many chemicals, it should be handled with caution due to potential toxicity and environmental concerns.

InChI:InChI=1/C9H8F3NO/c1-5(14)7-3-2-6(4-8(7)13)9(10,11)12/h2-4H,13H2,1H3

Upstream product

• 1483-54-1 2-amino-4-trifluoromethylbenzonitrile 
• 676-58-4 methylmagnesium chloride 
• 128403-22-5 2-nitro-4-trifluoromethyl-acetophenone 

Downstream Products

• 128403-24-7 N'-(2-Acetyl-5-trifluoromethyl-phenyl)-N,N-dimethyl-formamidine; hydrochloride 
• 128403-23-6 N-(2-Acetyl-5-trifluoromethyl-phenyl)-formamide 
• 346-55-4 4-chloro-7-trifluoromethyl quinoline 
• 880474-03-3 N-(2-acetyl-5-trifluoromethylphenyl)-trifluoromethanesulfonamide 
• 134019-43-5 2-Amino-4-trifluoromethylacetophenone phenylhydrazone 
• 1361108-20-4 N-[(3-fluorophenyl)-methyl]-4-methyl-2-oxo-1-(tetrahydro-pyran-4-yl)-7-(trifluoromethyl)-1H-quinoline-3-carboxylic acid amide 
• 1361108-29-3 ethyl 3-((2-acetyl-5-(trifluoromethyl)phenyl)(tetrahydro-2H-pyran-4-yl)amino)-3-oxopropanoate 
• 1361296-66-3 3 N-[(4-fluorophenyl)-methyl]-4-methyl-2-propyl-7-(trifluoromethyl)-quinoline-3-carboxylic acid amide 
• 1242555-24-3 3-(2-acetyl-5-(trifluoromethyl)phenylamino)-3-oxopropanoic acid ethyl ester 
• 1361107-79-0 1-butyl-N-[(3-fluorophenyl)-methyl]-4-methyl-2-oxo-7-(trifluoromethyl)-1H-quinoline-3-carboxylic acid amide 
• 1361107-78-9 N-[(3-fluorophenyl)-methyl]-1,4-dimethyl-2-oxo-7-(trifluoromethyl)-1H-quinoline-3-carboxylic acid amide 
• 1361108-22-6 N-[(3-fluorophenyl)-methyl]-4-methyl-2-oxo-7-(trifluoromethyl)-1H-quinoline-3-carboxylic acid amide 
• 1361108-28-2 1-(2-(tetrahydro-2H-pyran-4-ylamino)-4-(trifluoromethyl)phenyl)ethanone 
• 1361296-94-7 2-(dimethylaminomethyl)-N-[(3-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxylic acid amide 

Relevant articles and documents

Ir(iii)-Catalysed electrooxidative intramolecular dehydrogenative C-H/N-H coupling for the synthesis of N-H indoles

Herein, an iridium(iii)-catalysed electrooxidative intramolecular dehydrogenative C-H/N-H coupling of unprotected 2-alkenyl anilines is described. The developed method allows the synthesis of a variety of 3-substituted N-H indole scaffolds under undivided electrolytic conditions. Mechanistic studies suggest that the reaction proceeds through the electro-oxidation induced reductive elimination pathway.

N-PHENYL-1,1,1-TRIFLUOROMETHANESULFONAMIDE HYDRAZONE DERIVATIVE COMPOUNDS AND THEIR USAGE IN CONTROLLING PARASITES

Novel N-phenyl-1,1,1-trifluoromethanesulfonamide compounds useful for controlling endo and/or ectoparasites in the environment are provided, together with methods of making the same, and methods of using the inventive compounds to treat parasite infestations in vivo and ex vivo.

Addition of nitroalkanes toortho-halonitrobenzenes: A new synthesis of 4-chloro-7-(trifluoromethyl)quinoline

Base-mediated reaction of ortho-nitroaryl chlorides and fluorides with nitroalkanes followed by an oxidative Nef reaction provides aryl ketones. With this simple procedure, methylketone 6 was prepared in 91% yield. 6 was then converted in three steps (60-65% yield) to 4-chloro-7-(trifluoromethyl)quinoline (2), an intermediate in the synthesis of the antihypertensive agent losulazine (U-54,669, 1).