37885-07-7

Usage

Uses

Used in Pharmaceutical Research:
Ethanone,1-[2-amino-4-(trifluoromethyl)phenyl]is used as a key intermediate in the synthesis of various pharmaceutical drugs. Its unique molecular structure, featuring amino and trifluoromethyl groups, allows for the development of new drug candidates with potential therapeutic applications.
Used in Chemical Research:
Ethanone,1-[2-amino-4-(trifluoromethyl)phenyl]is used as a research tool in the field of organic chemistry, where it can be employed to study the reactivity and properties of ketones and other related compounds. Its presence in various chemical reactions can provide insights into the mechanisms and pathways involved, contributing to the advancement of chemical knowledge.
Used in Drug Development:
Ethanone,1-[2-amino-4-(trifluoromethyl)phenyl]is used as a building block in the design and synthesis of new drug molecules. Its incorporation into drug candidates can potentially enhance their pharmacological properties, such as potency, selectivity, and bioavailability, leading to the development of more effective therapeutic agents.
Used in Environmental Monitoring:
Due to its potential toxicity and environmental concerns, Ethanone,1-[2-amino-4-(trifluoromethyl)phenyl]is also used in environmental monitoring programs to detect and quantify its presence in various ecosystems. This helps in assessing the impact of this chemical on the environment and implementing appropriate measures to mitigate any adverse effects.

InChI:InChI=1/C9H8F3NO/c1-5(14)7-3-2-6(4-8(7)13)9(10,11)12/h2-4H,13H2,1H3

Upstream product

• 128403-22-5 2-nitro-4-trifluoromethyl-acetophenone 
• 1483-54-1 2-amino-4-trifluoromethylbenzonitrile 
• 676-58-4 methylmagnesium chloride 

Downstream Products

• 128403-24-7 N'-(2-Acetyl-5-trifluoromethyl-phenyl)-N,N-dimethyl-formamidine; hydrochloride 
• 128403-23-6 N-(2-Acetyl-5-trifluoromethyl-phenyl)-formamide 
• 134019-43-5 2-Amino-4-trifluoromethylacetophenone phenylhydrazone 
• 1361108-20-4 N-[(3-fluorophenyl)-methyl]-4-methyl-2-oxo-1-(tetrahydro-pyran-4-yl)-7-(trifluoromethyl)-1H-quinoline-3-carboxylic acid amide 
• 1361108-29-3 ethyl 3-((2-acetyl-5-(trifluoromethyl)phenyl)(tetrahydro-2H-pyran-4-yl)amino)-3-oxopropanoate 
• 884494-59-1 3-methyl-6-trifluoromethyl-1H-indole 
• 1360684-86-1 2-ethylamino-N-[(3-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxylic acid amide 
• 1242554-98-8 2-chloro-N-(3-fluorobenzyl)-4-methyl-7-(trifluoromethyl) quinoline-3-carboxylic acid amide 
• 1361296-94-7 2-(dimethylaminomethyl)-N-[(3-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxylic acid amide 
• 1361108-28-2 1-(2-(tetrahydro-2H-pyran-4-ylamino)-4-(trifluoromethyl)phenyl)ethanone 
• 1361108-22-6 N-[(3-fluorophenyl)-methyl]-4-methyl-2-oxo-7-(trifluoromethyl)-1H-quinoline-3-carboxylic acid amide 

Relevant academic research and scientific papers

Ir(iii)-Catalysed electrooxidative intramolecular dehydrogenative C-H/N-H coupling for the synthesis of N-H indoles

Herein, an iridium(iii)-catalysed electrooxidative intramolecular dehydrogenative C-H/N-H coupling of unprotected 2-alkenyl anilines is described. The developed method allows the synthesis of a variety of 3-substituted N-H indole scaffolds under undivided electrolytic conditions. Mechanistic studies suggest that the reaction proceeds through the electro-oxidation induced reductive elimination pathway.

Water-Soluble Hypervalent Iodine(III) Having an I-N Bond. A Reagent for the Synthesis of Indoles

A readily accessible and bench-stable water-soluble hypervalent iodine(III) reagent (phenyliodonio)sulfamate (PISA) with an I-N bond was synthesized, and its structure was characterized by X-ray crystallography. With PISA, various indoles were synthesized via C-H amination of 2-alkenylanilines involving an aryl migration/intramolecular cyclization cascade with excellent regioselectivity in aqueous CH3CN. Notably, using this new method as the key step, not only two drug molecules, indometacin and zidometacin, but also another bioactive molecule, pravadoline, were synthesized.

N-PHENYL-1,1,1-TRIFLUOROMETHANESULFONAMIDE HYDRAZONE DERIVATIVE COMPOUNDS AND THEIR USAGE IN CONTROLLING PARASITES

Novel N-phenyl-1,1,1-trifluoromethanesulfonamide compounds useful for controlling endo and/or ectoparasites in the environment are provided, together with methods of making the same, and methods of using the inventive compounds to treat parasite infestations in vivo and ex vivo.

Control of parasites in animals by the use of novel trifluoromethanesulfonanilide oxime ether derivatives

Novel trifluoromethanesulfonanilide oxime ether compounds useful for controlling endo and/or ectoparasites in the environment are provided, together with methods of making the same, and methods of using the inventive compounds to treat parasite infestations in vivo or ex vivo.

Addition of nitroalkanes toortho-halonitrobenzenes: A new synthesis of 4-chloro-7-(trifluoromethyl)quinoline

Base-mediated reaction of ortho-nitroaryl chlorides and fluorides with nitroalkanes followed by an oxidative Nef reaction provides aryl ketones. With this simple procedure, methylketone 6 was prepared in 91% yield. 6 was then converted in three steps (60-65% yield) to 4-chloro-7-(trifluoromethyl)quinoline (2), an intermediate in the synthesis of the antihypertensive agent losulazine (U-54,669, 1).