119295-86-2

Upstream product

• 38078-09-0 diethylamino-sulfur trifluoride 
• 144-55-8 sodium hydrogencarbonate 
• 119288-15-2 3β-benzoyloxylanost-7-en-15α-ol 
• 309958-29-0 Benzoic acid (3S,5R,10S,13R,14S,15S,17R)-17-((R)-1,5-dimethyl-hexyl)-15-hydroxy-4,4,10,13-tetramethyl-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester 
• 103399-80-0 Benzoic acid (3S,5R,9R,10R,13R,17R)-17-((R)-1,5-dimethyl-hexyl)-4,4,10,13-tetramethyl-15-oxo-2,3,4,5,6,7,9,10,11,12,13,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester 
• 119288-11-8 3β-benzoyloxy-4,4-dimethyl-5α,14β-cholest-8-en-15-one 
• 309958-30-3 Benzoic acid (3S,5R,9R,10R,13R,14R,15S,17R)-17-((R)-1,5-dimethyl-hexyl)-15-hydroxy-4,4,10,13-tetramethyl-2,3,4,5,6,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester 
• 119288-17-4 3β-benzoyloxy-4,4-dimethyl-5α-cholest-7-en-15-one 
• 309958-27-8 Benzoic acid (3S,5R,8R,9S,10R,13R,17R)-17-((R)-1,5-dimethyl-hexyl)-4,4,10,13-tetramethyl-2,3,4,5,6,7,8,9,10,11,12,13,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester 
• 16826-35-0 cholesta-4,7-dien-3-one 
• 103399-79-7 (3β,5α,20R)-4,4-dimethylcholesta-8,14-dien-3-ol benzoate 
• 116928-45-1 3β-benzoyloxy-32-nor-lanost-8(14)-ene 
• 108348-03-4 15-oxolanost-7-en-3β-yl benzoate 
• 14772-51-1 32-nor-lanost-8(14)-en-3β-ol 

Downstream Products

• 309958-33-6 15α-fluoro-8-lanost-8-en-3β-yl benzoate 

Relevant academic research and scientific papers

Synthesis of 15alpha-fluoro-24,25-dihydrolanosterol as a potential inhibitor and/or mechanistic probe for lanosterol 14alpha-demethylase.

As a potential inhibitor and/or mechanistic probe for lanosterol 14alpha-demethylase, 15alpha-fluoro-24,25-dihydrolanosterol was prepared by fluorination of 15alpha-hydroxy-24,25-dihydrolanost-7-en-3beta-yl benzoate with diethylaminosulfur trifluoride, followed by hydrogen chloride-catalyzed isomerization of the delta7 to delta8 and reductive cleavage of the benzoate.

STEROID DERIVATIVES USEFUL AS HYPOCHOLESTEROLEMICS

Lanosterols substituted in the 14 and/or 15 position(s) which are active in inhibiting lanosta-8,24-dien-3β-ol 14α-methyl-demethylase activity, suppressing 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) activity, decreasing cholesterol s