1192966-53-2Relevant academic research and scientific papers
Redox Economic Synthesis of TrisubstitutedPiperidones via Ruthenium Catalyzed Atom-Economic Couplings of N-Protected 1,5-Aminoalcohols and Michael Acceptors
Trost, Barry M.,Sarkar, Debayan,Bera, Nabakumar
, p. 5648 - 5653 (2019)
An efficient atom-economic coupling of 1,5-amino alcohols and Michael acceptors has been developed employing [CpRu(MeCN)3]PF6 as a key catalyst to synthesize α,β-unsaturated ketones with exclusive generation of E-geometrical isomers at room temperature without any co-catalyst and additives. A base catalysed 6-endo-trig cyclization of the α,β-unsaturated ketone delivers a direct access to tri-substituted piperidones.
An efficient, practical, and enantioselective method for synthesis of homoallenylamides catalyzed by an aminoalcohol-derived, boron-based catalyst
Wu, Hao,Haeffner, Fredrik,Hoveyda, Amir H.
, p. 3780 - 3783 (2014/04/03)
A practical catalytic method for enantioselective addition of an allene unit to aldimines is disclosed. Transformations are promoted by an in-situ-generated B-based catalyst that is derived from a simple, robust, and readily accessible (in multigram quantities) chiral aminoalcohol. A range of aryl-, heteroaryl-, and alkyl-substituted homoallenylamides can be obtained in 66-91% yield and 84:16 to >99:1 enantiomeric ratio through reactions performed at ambient temperature and in the presence of 0.1-3.0 mol% of the chiral catalyst and a commercially available allenylboron reagent. The catalytic protocol does not require strict anhydrous conditions, can be performed on gram scale, and promotes highly selective addition of an allenyl unit (vs a propargyl group). The utility of the approach is demonstrated through development of succinct approaches to syntheses of anisomycin and epi-cytoxazone.
ALPHA2B AND ALPHA2C AGONISTS
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Page/Page column 9, (2009/12/02)
Described herein are compounds that can be useful as bioactive agents. More specifically, the compounds described herein can be useful as both α2B and α2C adrenergic agonists. Methods of synthesis and administration of the compounds are also disclosed.
