119304-74-4Relevant academic research and scientific papers
NOVEL 5-HT2 ANTAGONISTS
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Paragraph 0071; 0104, (2017/01/05)
The present invention relates to 1-amidino-3-aryl-2-pyrazoline derivatives of the general formula I The invention specifically relates to such derivatives which exhibit antagonizing activity towards serotonin 5-HT2B receptors. The present invention also relates to use of said compounds as a medicament and for the treatment of fibrosis, cardiovascular diseases, pain, IBD, and other inflammatory diseases, as well as pharmaceutical compositions comprising one or more of said compounds and methods of treatment.
The Mannich Reaction of 1-(2-Hydroxyphenyl)-1-ethanone, -1-propanone and -1-butanone, and 1-(2-Hydroxy-5-methylphenyl)-2-phenyl-1-ethanone
Joglekar, S. J.,Samant, S. D.
, p. 830 - 832 (2007/10/02)
The title compounds on reaction with secondary amines in the presence of formaldehyde under acidic condition, gave the corresponding Mannich bases by ω-aminomethylation.
