119326-95-3Relevant academic research and scientific papers
MK2 INHIBITORS AND USES THEREOF
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Paragraph 00645, (2014/10/03)
The present invention provides compounds, compositions thereof, and methods of using the same.
Decarboxylation of 1-Aminocyclopropanecarboxylic Acid and Its Derivatives
Vaidyanathan, Ganesan,Wilson, Joseph W.
, p. 1810 - 1815 (2007/10/02)
The question of whether the title compounds could be decarboxylated to cyclopropanone derivatives was answered in the affirmative by the following observations. (1) Compound 11a was decarboxylated by 1,2,3-indantrione in acetonitrile, benzene, or methanol.The initially formed intermediate could be trapped by N-phenylmaleimide (to form 3), by diethyl azodicarboxylate (to form an unstable adduct), by ninhydrin itself (to form 5) or by a proton (in methanol, to form 8). (2) Compound 11d was decarboxylated by phenylbis(trifluoroacetato-O)iodine to yield carbinolamine 12d.cis-2,3-Dideuterio-11d yielded cis-2,3-dideuterio-12d under the same conditions. (3) ACC was decarboxylated by phenanthroquinone to yield oxazole 9, probably by way of oxazoline 10.
