1193376-97-4Relevant academic research and scientific papers
"PROCESS FOR THE PREPARATION OF MACROCYCLIC KETONE ANALOGS OF HALICHONDRIN B OR PHARMACEUTICALLY ACCEPTABLE SALTS AND INTERMEDIATES THEREOF"
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, (2016/06/01)
The present invention discloses a novel process for the preparation of macrocyclic ketone analogs of halichondrin B or pharmaceutically acceptable salts thereof and to novel intermediates which are produced during the course of carrying out the novel proc
New syntheses of E7389 C14-C35 and halichondrin C14-C38 building blocks: Reductive cyclization and oxy-Michael cyclization approaches
Dong, Cheng-Guo,Henderson, James A.,Kaburagi, Yosuke,Sasaki, Takeo,Kim, Dae-Shik,Kim, Joseph T.,Urabe, Daisuke,Guo, Haibing,Kishi, Yoshito
supporting information; experimental part, p. 15642 - 15646 (2010/01/29)
Cr-mediated coupling reactions are usually achieved with a slight excess of a given nucleophile. To develop a cost-effective use of this process, two different approaches have been studied. The first approach depends on two consecutive catalytic asymmetri
New syntheses of E7389 C14-C35 and halichondrin C14-C38 building blocks: Double-inversion approach
Kim, Dae-Shik,Dong, Cheng-Guo,Kim, Joseph T.,Guo, Haibing,Huang, Jian,Tiseni, Paolo S.,Kishi, Yoshito
supporting information; experimental part, p. 15636 - 15641 (2010/01/30)
With sequential use of catalytic asymmetric Cr-mediated coupling reactions, E7389 C14-C35 and halichondrin C14-C38 building blocks have been stereoselectively synthesized. The C19-C20 bond is first formed via the catalytic asymmetric Ni/Cr-mediated coupli
