546141-41-7

Upstream product

• 871348-16-2 (2R,3R,4R,5S)-5-allyl-2-(((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-4-((phenylsulfonyl)methyl)tetrahydrofuran-3-ol 
• 74-88-4 methyl iodide 
• 56069-39-7 diethyl phenylsulfonylmethylphosphonate 
• 871348-03-7 C₃₁H₃₂O₈ 
• 546141-24-6 [(2S)-3-[(2R,3R,4S,5S)-5-allyl-3-benzyloxy-4-hydroxytetrahydrofuran-2-yl]-2-benzoyloxypropyl]benzoate 
• 871348-04-8 [(2S)-3-[(2R,3S,5S)-5-allyl-3-benzyloxy-4-oxo-tetrahydrofuran-2-yl]-2-benzoyloxypropyl] benzoate 
• 871348-06-0 C₃₈H₃₆O₈S 
• 871348-08-2 C₃₁H₃₀O₈S 
• 546141-26-8 C₃₁H₃₂O₈S 
• 871348-10-6 (2R,3R,4R,5S)-5-allyl-2-[(S)-2,3-dihydroxypropyl]-4-[(phenylsulfonyl)methyl]tetrahydrofuran-3-ol 

Downstream Products

• 253128-10-8 3-((2S,5S)-5-(2-((2S,4R,6R)-6-(((2S,3S,4R,5R)-5-((S)-2,3-bis((tert-butyldimethylsilyl)oxy)propyl)-4-methoxy-3-((phenylsulfonyl)methyl)tetrahydrofuran-2-yl)methyl)-4-methyl-5-methylenetetrahydro-2H-pyran-2-yl)ethyl)-4-methylenetetrahydrofuran-2-yl)propan-1-ol 
• 871348-22-0 C₃₀H₅₄O₆SSi₂ 
• 871348-24-2 2-((2S,3S,4R,5R)-5-((S)-2,3-bis((tert-butyldimethylsilyl)oxy)propyl)-4-methoxy-3-((phenylsulfonyl)methyl)tetrahydrofuran-2-yl)acetaldehyde 
• 1424343-99-6 C₅₁H₉₀O₁₃S₂Si₂ 
• 253128-09-5 3-((2S,5S)-5-(2-((2S,4R,6R)-6-(((2S,3S,4R,5R)-5-((S)-2,3-bis((tert-butyldimethylsilyl)oxy)propyl)-4-methoxy-3-((phenylsulfonyl)methyl)tetrahydrofuran-2-yl)methyl)-4-methyl-5-methylenetetrahydro-2H-pyran-2-yl) ethyl)-4-methylenetetrahydrofuran-2-yl)propyl pivalate 
• 1193376-97-4 C₅₂H₇₂O₉SSi 
• 546141-40-6 C₁₈H₂₆O₆S 

Relevant academic research and scientific papers

PROCESS FOR PREPARATION OF ERIBULIN AND INTERMEDIATES THEREOF

The present application relate to a process for preparation of 4-methylene tetrahydrofuran compound of formula II, which is useful as an intermediate for the preparation of halichondrin B analogues such as eribulin and its pharmaceutically acceptable salts thereof. The present application also provide crystalline compound of formula III and crystalline compound of formula II.

Process development of halaven: Synthesis of the C14-C35 fragment via iterative nozaki-hiyama-kishi reaction-williamson ether cyclization

Multikilogram manufacturing process of the Halaven C14-C35 fragment is described. The synthesis features convergent assembly of subunits by iterative asymmetric Ni/Cr-mediated coupling executed in fixed equipment. Georg Thieme Verlag Stuttgart - New York.

INTERMEDIATES FOR THE PREPARATION OF HALICHONDRIN B

The present invention provides macrocyclic compounds, synthesis of the same and intermediates thereto. Such compounds, and compositions thereof, are useful for treating or preventing proliferative disorders Formula (F-4).