1193386-10-5

Basic information

• Product Name: 3-(2-methylphenyl)-3-(4-methylphenyl)propionic acid
• Synonyms: 3-(2-methylphenyl)-3-(4-methylphenyl)propionic acid
• CAS NO: 1193386-10-5
• Molecular Weight: 254.329
• Mol File: 1193386-10-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(2-methylphenyl)-3-(4-methylphenyl)propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-methylphenyl)-3-(4-methylphenyl)propionic acid(1193386-10-5)
• EPA Substance Registry System: 3-(2-methylphenyl)-3-(4-methylphenyl)propionic acid(1193386-10-5)

Safety Data

• Hazardous Substances Data: 1193386-10-5(Hazardous Substances Data)

Upstream product

• 108-88-3 toluene 
• 471-25-0 Propiolic acid 
• 2373-76-4 2-methylcinnamic acid 

Relevant articles and documents

A high hydroarylation activity of K2PtCl4/AgOTf catalyst in the reaction of propiolic acid with unactivated and activated arenes

A mixed catalyst K2PtCl4/AgOTf showed the highest activity for hydroarylation of propiolic acid, among palladium and platinum catalysts. This catalyst was effective for hydroarylation with less reactive benzene to give cis-cinnamic acid in good yield. The hydroarylation with toluene gave a higher yield of hydroarylation products than that with benzene and resulted in ortho/para orientation with an almost statistical ratio, suggesting that the result is very close to that of the Friedel-Crafts alkylation with methyl bromide or p-nitrobenzyl chloride. Hydroarylation of propiolic acid with other electron-rich arenes proceeded efficiently in the presence of the K2PtCl4/AgOTf catalyst in trifluoroacetic acid forming cis-cinnamic acids in good to high yields. This method was also applied to hydroarylation of ethyl propiolate.