119346-07-5Relevant academic research and scientific papers
Enantioselective bromoaminocyclization using amino-thiocarbamate catalysts
Zhou, Ling,Chen, Jie,Tan, Chong Kiat,Yeung, Ying-Yeung
supporting information; experimental part, p. 9164 - 9167 (2011/08/04)
A facile and efficient enantioselective bromoaminocyclization of unsaturated sulfonamides has been developed using an amino-thiocarbamate catalyst. A range of enantioenriched pyrrolidines were prepared with up to 99% yield and 99% ee. The corresponding lactams could be obtained through oxidation of the pyrrolidines.
Asymmetric bromolactonization using amino-thiocarbamate catalyst
Zhou, Ling,Tan, Chong Kiat,Jiang, Xiaojian,Chen, Feng,Yeung, Ying-Yeung
supporting information; experimental part, p. 15474 - 15476 (2011/02/21)
A novel amino-thiocarbamate-catalyzed bromolactonization of unsaturated carboxylic acids has been developed. The scope of the reaction is evidenced by 22 examples of γ-lactones with up to 99% yield and 93% ee. The protocol was applied in the enantioselective synthesis of the key intermediates of VLA-4 antagonists.
A NOVEL APPROACH TO THE 5a-ARYLDECAHYDRO-2-BENZAZEPINE SKELETON
Handa, Sheetal,Jones, Keith,Newton, Christopher G.
, p. 3841 - 3844 (2007/10/02)
Trienes (3) are prepared and their intramolecular cyclisation to give the 5a-aryloctahydrobenzazepines (6) is described.
