119346-08-6

Upstream product

• 119346-07-5 4-(3-Methoxy-phenyl)-pent-4-enoic acid methyl ester 
• 25108-57-0 3-(1-methylethenyl)anisole 
• 119346-06-4 3-bromo-2-(3-methoxyphenyl)propane-1,2-diol 
• 119346-05-3 Acetic acid 2-(3-methoxy-phenyl)-allyl ester 
• 586-37-8 1-(3-Methoxyphenyl)ethanone 

Downstream Products

• 119346-12-2 4-(3-Methoxy-phenyl)-pent-4-enoyl chloride 
• 119346-16-6 [4-(3-Methoxy-phenyl)-pent-4-enyl]-methyl-amine 
• 119346-09-7 (5aR,7S)-5a-(3-Methoxy-phenyl)-2,7-dimethyl-2,3,4,5,5a,6,7,8-octahydro-1H-benzo[c]azepine 
• 119346-14-4 (2E,4E)-Hexa-2,4-dienoic acid [4-(3-methoxy-phenyl)-pent-4-enyl]-methyl-amide 
• 119346-01-9 (5aS,7S,9aR)-5a-(3-Methoxy-phenyl)-2,7-dimethyl-decahydro-benzo[c]azepine 
• 119346-15-5 (5aR,7S)-5a-(3-Methoxy-phenyl)-2,7-dimethyl-2,3,4,5,5a,6,7,8-octahydro-benzo[c]azepin-1-one 
• 119346-13-3 4-(3-Methoxy-phenyl)-pent-4-enoic acid methylamide 
• 1254701-76-2 (S)-5-(bromomethyl)-5-(3-methoxyphenyl)dihydrofuran-2(3H)-one 

Relevant academic research and scientific papers

Asymmetric bromolactonization using amino-thiocarbamate catalyst

A novel amino-thiocarbamate-catalyzed bromolactonization of unsaturated carboxylic acids has been developed. The scope of the reaction is evidenced by 22 examples of γ-lactones with up to 99% yield and 93% ee. The protocol was applied in the enantioselective synthesis of the key intermediates of VLA-4 antagonists.

A NOVEL APPROACH TO THE 5a-ARYLDECAHYDRO-2-BENZAZEPINE SKELETON

Trienes (3) are prepared and their intramolecular cyclisation to give the 5a-aryloctahydrobenzazepines (6) is described.