119348-72-0

Basic information

• Product Name: 5-[4-(4-Acetyl-3-hydroxy-2-propyl-benzyloxy)-2-hydroxy-phenyl]-5-oxo-pentanenitrile
• Synonyms: 5-[4-(4-Acetyl-3-hydroxy-2-propyl-benzyloxy)-2-hydroxy-phenyl]-5-oxo-pentanenitrile
• CAS NO: 119348-72-0
• Molecular Weight: 395.455
• Mol File: 119348-72-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-[4-(4-Acetyl-3-hydroxy-2-propyl-benzyloxy)-2-hydroxy-phenyl]-5-oxo-pentanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[4-(4-Acetyl-3-hydroxy-2-propyl-benzyloxy)-2-hydroxy-phenyl]-5-oxo-pentanenitrile(119348-72-0)
• EPA Substance Registry System: 5-[4-(4-Acetyl-3-hydroxy-2-propyl-benzyloxy)-2-hydroxy-phenyl]-5-oxo-pentanenitrile(119348-72-0)

Safety Data

• Hazardous Substances Data: 119348-72-0(Hazardous Substances Data)

Upstream product

• 151-10-0 1,3-Dimethoxybenzene 
• 135312-45-7 5-(2,4-dimethoxyphenyl)-5-oxopentanenitrile 
• 4654-07-3 5-(2,4-dimethoxyphenyl)-5-oxopentanoic acid 
• 108-55-4 glutaric anhydride, 
• 135312-44-6 5-(2,4-dihydroxyphenyl)-5-oxopentanenitrile 
• 97582-36-0 1-<4-(chloromethyl)-2-hydroxy-3-propylphenyl>ethanone 

Downstream Products

• 119348-45-7 1-{4-[(4-Acetyl-3-hydroxy-2-propylphenyl)methoxy]-2-hydroxyphenyl}-4-(1H-tetrazol-5-yl)-1-butanone 

Relevant articles and documents

(Phenylmethoxy)phenyl Derivatives of Ω-Oxo- and Ω-Tetrazolylalkanoic Acids and Related Tetrazoles. Synthesis and Evaluation as Leukotriene D4 Receptor Antagonists

Two series of (phenylmethoxy)phenyl compounds derived from the structure of LY163443 were synthesized and evaluated as leukotriene D4 receptor antagonists.In the Ω--Ω-oxoalkanoic acid series, 5-phenyl>-3,3-dimethyl-5-oxopentanoic acid (8) was the most potent antagonist of LTD4-induced contractions of guinea pig ileum (pKB of 7.60) and LTD4 pressor response in pithed rats (ED50 of 1.4 mg/kg iv).Replacing the carboxylic acid function with 5-tetrazole gave slightly more potent compounds.Inthe Ω-alkyl>tetrazolyl>alkanoic acid series, replacing the carboxylic acid with 5-tetrazole gave compounds that were equally effective in the guinea pig ileum but more potent in vivo against the LTD4 pressor response in rat.The pKB value in the guinea pig ileum for 1--2H-tetrazol-5-yl>methyl>phenoxy>methyl>phenyl>ethanone (25) was 7.87 and the ED50 for antagonism of the LTD4 pressor response was 4.0 mg/kg iv.The sodium salts of 8 (9) and 25(26) given by the iv route of administration antagonized LTD4-induced cardiovascular alterations in anesthetized rat and LTD4-induced bronchoconstriction in guinea pig in a dose-dependent manner.Oral activity was also demonstrated against the LTD4-induced bronchoconstriction in guinea pig.