4654-07-3Relevant articles and documents
IRE-1α INHIBITORS
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Paragraph 1226; 1227, (2016/10/07)
PROBLEM TO BE SOLVED: To provide compounds which directly inhibit inositol requiring enzyme 1 (IRE-1α activity) in vitro, prodrugs, and pharmaceutically acceptable salts thereof. SOLUTION: The present invention provides a compound represented by formula (A) [R3 and R4 are H or the like; Q5-Q8, together with the benzene ring to which they are attached, form a benzofused ring, where at least one of Q5-Q8 is a heteroatom selected from N, O, and S. COPYRIGHT: (C)2016,JPOandINPIT
Studies on Cannabinoids: Part IV - Synthesis of 9,10,11,11a-Tetrahydro-3-methoxy-6H,8H-pyridobenzoxazine Involving an Unusual Case of Demethylation by Lithium Aluminium Hydride
Malik, O. P.,Kapil, R. S.,Anand, Nitya
, p. 912 - 914 (2007/10/02)
The synthesis of title compound is described by condensation of 2-(2'-hydroxy-4'-methoxyphenyl)piperidine (10) with methylene bromide.The former in turn is obtained by selective demethylation of on of the methoxy groups during the LAH reduction of 6-(2',4