119353-18-3Relevant academic research and scientific papers
Copper-Catalyzed Alkynylation of C(sp3)?H Bonds in N-Fluoro-sulfonamides
Yin, Zhiping,Zhang, Youcan,Zhang, Shuo,Wu, Xiao-Feng
supporting information, p. 5478 - 5482 (2019/11/11)
Herein, we developed a copper-catalyzed approach for the remote C(sp3)?H alkynylation of N-fluoro-sulfonamides. With Cu(OTf)2 as the catalyst, the carbon radical which generated from nitrogen radical-mediated 1,5-hydrogen atom transf
Radical Alkynyltrifluoromethylation of Alkenes Initiated by an Electron Donor-Acceptor Complex
Jiang, Heng,He, Yanyan,Cheng, Yuanzheng,Yu, Shouyun
supporting information, p. 1240 - 1243 (2017/03/14)
Radical alkynyltrifluoromethylation of alkenes with actylenic triflones has been achieved. This radical chain reaction is initiated by a catalytic amount of an electron-donor-acceptor complex composed of Togni’s reagent and N-methylmorpholine. This transf
Perfluoroalkanesulfonylation of Alkynyl(phenyl)iodonium Tosylates by the Weakly Nucleophilic Sodium Perfluoroalkanesulfinates
Han, Jia-Bin,Yang, Lian,Chen, Xing,Zha, Gao-Feng,Zhang, Cheng-Pan
, p. 4119 - 4124 (2016/12/30)
An additive- and transition metal-free perfluoroalkanesulfonylation of alkynyl(phenyl)iodonium tosylates with sodium perfluoroalkanesulfinates (RfnSO2Na) is described. The poorly nucleophilic RfnSO2Na reacted with alkynyl(phenyl)iodonium salts in dichloromethane at room temperature under a nitrogen atmosphere for 5–60 minutes to afford a variety of acetylenic triflones and alkynyl perfluoroalkyl sulfones in good to quantitative yields. The position of substituents on the phenyl rings of the arylethynyl moiety in the iodonium salts had a big influence on the reaction. The formation of five-membered cyclic vinyl sulfones suggested that the reaction proceeds via an alkylidene carbene intermediate. Furthermore, successful scaling-up of the reaction demonstrates the practicality of the new method. Advantages of the method include short reaction times, mild conditions, and the easy access to perfluoroalkanesulfonylation reagents (RfnSO2Na). (Figure presented.).
Copper-Catalyzed Trifluoromethylalkynylation of Isocyanides
Lei, Jian,Wu, Xiaoxing,Zhu, Qiang
supporting information, p. 2322 - 2325 (2015/06/02)
The title reaction proceeds with acetylenic triflones and isocyanides under mild conditions using copper as a catalyst. This transformation provides an efficient access to (E)-N-alkyl trifluoromethyl alkynyl ketoimines, which are useful building blocks for the synthesis of CF3-containing N-heterocycles, propargylamines, etc.
An Expedient Synthesis of Alkynyl Trifluoromethyl Sulfones
Hanack, Michael,Wilhelm, Baerbl,Subramanian, L. R.
, p. 592 - 595 (2007/10/02)
The hiterto difficultly attainable trifluoromethyl sulfones 7 were prepared by the reaction of alkynyl sodium salts 6 with trifluoromethanesulfonic anhydride (1) in modest to good yields.The reactivity of 7 with different nucleophiles was studied.
