119368-45-5

Upstream product

• 3938-96-3 ethyl 2-methoxyacetate 
• 105-58-8 Diethyl carbonate 
• 122-01-0 4-chloro-benzoyl chloride 

Downstream Products

• 857622-85-6 N-acetyl-sulfanilic acid-(4-ethoxy-5-methoxy-6-methoxymethyl-pyrimidin-2-ylamide) 
• 857622-99-2 N-acetyl-sulfanilic acid-(4,5-dimethoxy-6-methoxymethyl-pyrimidin-2-ylamide) 
• 857621-70-6 N-acetyl-sulfanilic acid-(5-methoxy-4-methoxymethyl-pyrimidin-2-ylamide) 
• 19175-00-9 4-amino-N-(5-methoxy-4-methoxymethyl-pyrimidin-2-yl)-benzenesulfonamide 

Relevant academic research and scientific papers

A novel route to 4-oxy/thio substituted-1H-pyrazol-5(4H)-ones via efficient cross-Claisen condensation

α-Oxy/thio substituted β-keto esters were synthesized through an efficient cross-Claisen condensation of oxy/thio substituted acetic acid ethyl esters with acid chlorides, which in turn converted in situ into 4-oxy/thio substituted-1H-pyrazol-5(4H)-ones by the addition of hydrazine and its derivatives. This method has been found to be extremely fast, general, and useful toward the synthesis of inaccessible pyrazolones and synthetically demanding 4-oxy/thio substituted pyrazolones.

Carba-acyclonucleoside antiherpetic agents

Ganciclovir 2 and 2'-carba-ganciclovir 5a are anti-viral agents differing structurally only in the replacement of an oxygen by a methylene group and yet expressing their biological properties along mechanistically independent pathways. Methoxy, hydroxy an