119372-44-0

Upstream product

• 20299-41-6 (S)-2-Benzyloxycarbonylamino-3-(4-nitro-phenyl)-propionic acid methyl ester 

Downstream Products

• 119372-54-2 (S)-4-Benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-5-(4-nitro-phenyl)-pentanoic acid ethyl ester 
• 119351-74-5 [(S)-4-tert-Butoxycarbonylamino-3,3-difluoro-2-hydroxy-1-(4-nitro-benzyl)-butyl]-carbamic acid benzyl ester 
• 119351-64-3 [(S)-3-Carbamoyl-3,3-difluoro-2-hydroxy-1-(4-nitro-benzyl)-propyl]-carbamic acid benzyl ester 
• 119860-09-2 [(S)-4-Amino-3,3-difluoro-2-hydroxy-1-(4-nitro-benzyl)-butyl]-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Compounds and Compositions as Channel Activating Protease Inhibitors

The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for, using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.

A CONVENIENT SYNTHESIS OF &α',&β-DIAMINO- &α,&α-DIFLUOROKETONES, NEW DIPEPTIDE ISOSTERES

A convenient and versatile synthesis of α',β-diamino-α,α-difluoroketones is described.These compounds represent a new class of true dipeptide isosteres useful for the design of serine protease inhibitors.