119372-46-2Relevant academic research and scientific papers
ANALOG OF PEPTIDASE SUBSTRATES
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, (2008/06/13)
This invention relates to novel analogs of certain peptidase substrates in which the nitrogen atom of the scissile amide bond has been replaced with a difluoromethylene moiety and in which the carbonyl moiety of its adjacent amide bond has been replaced w
Novel peptidase inhibitors
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, (2008/06/13)
This invention relates to analogs of peptidase substrates in which the nitrogen atom of the scissile amide bond of a partial retropeptide analog of the substrate has been replaced by a difluoromethylene moiety. These peptidase substrate analogs provide specific enzyme inhibitors for a variety of proteases, the inhibition of which exert valuable pharmacological activities and therefore have useful physiological consequences in a variety of disease states.
Novel peptidase inhibitors
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, (2008/06/13)
This invention relates to activated electrophilic ketone retroamide analogs of certain peptidase substrates having the formula R1NHCHR2COCF2CHR3(NRbCOXRa)nQ These compounds are useful in inhibiting serine-, thiol-, carboxylic acid- and metallo- dependent
A CONVENIENT SYNTHESIS OF &α',&β-DIAMINO- &α,&α-DIFLUOROKETONES, NEW DIPEPTIDE ISOSTERES
Schirlin, D.,Baltzer, S.,Altenburger, J. M.
, p. 3687 - 3690 (2007/10/02)
A convenient and versatile synthesis of α',β-diamino-α,α-difluoroketones is described.These compounds represent a new class of true dipeptide isosteres useful for the design of serine protease inhibitors.
