1193753-07-9Relevant academic research and scientific papers
Palladium-catalyzed direct carboxylation of aryl bromides with carbon dioxide
Correa, Arkaitz,Martin, Ruben
supporting information; experimental part, p. 15974 - 15975 (2010/02/15)
(Chemical Equation Presented) A novel protocol for the direct carbon dioxide insertion (CO2) into aryl halides in a catalytic manner is presented herein. Unlike other carboxylation methods using CO2, there is no need for the synthesis of the corresponding organometallic intermediates. Additionally, and in contrast to the well-established carbonylation processes, our protocol does not use highly toxic CO for the preparation of benzoic acids. Furthermore, this method is distinguished by its mild conditions, allowing the tolerance of a wide range of functional groups and substitution patterns. The crucial step of the process involves a challenging catalytic CO2 insertion into Pd-C bonds. Copyright
