1193753-08-0Relevant articles and documents
Palladium-catalyzed direct carboxylation of aryl bromides with carbon dioxide
Correa, Arkaitz,Martin, Ruben
, p. 15974 - 15975 (2009)
(Chemical Equation Presented) A novel protocol for the direct carbon dioxide insertion (CO2) into aryl halides in a catalytic manner is presented herein. Unlike other carboxylation methods using CO2, there is no need for the synthesis of the corresponding organometallic intermediates. Additionally, and in contrast to the well-established carbonylation processes, our protocol does not use highly toxic CO for the preparation of benzoic acids. Furthermore, this method is distinguished by its mild conditions, allowing the tolerance of a wide range of functional groups and substitution patterns. The crucial step of the process involves a challenging catalytic CO2 insertion into Pd-C bonds. Copyright
Process for the carboxylation of aryl halides with palladium catalysts
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Page/Page column 9, (2011/05/04)
A process for the carboxylation of an aryl halide to yield an aryl carboxylic acid, in which the aryl halide and CO2 are contacted in an organic solvent under inert atmosphere and in the presence of a reducing agent and an adequate catalyst system.
