119377-27-4Relevant articles and documents
NEW RENIN-INHIBITORY OLIGOPEPTIDES, THEIR PREPARATION AND THEIR USE
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, (2008/06/13)
Oligopeptides of formula (I): STR1 where R 1-R 5 are various organic groups, and A represents a group of formula--NH--or--(CH 2) n--, in which n represents an integer of from 1 to 3, have renin-inhibitory activity and are particularly suitable for oral administration. They may be prepared by condensing their component amino acids or lower oligopeptides using conventional peptide synthesis reactions.
Renin inhibitors containing a pyridyl amino diol derived C-terminus
Heitsch,Henning,Kleemann,Linz,Nickel,Ruppert,Urbach,Wagner
, p. 2788 - 2800 (2007/10/02)
Based on the concept of transition-state analogs, a series of nonpeptide renin inhibitors with the new (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy- 6-(2-pyridyl)hexane moiety at the C-terminal functionality were synthesized and evaluated for inhibition
