1194041-98-9Relevant academic research and scientific papers
An efficient synthesis of N-arylsulfonylindoles from indoles and arylsulfonyl chlorides in the presence of triethylbenzylammonium chloride (TEBA) and NaOH
Xu, Hui,Wang, Yangyang
, p. 125 - 127 (2010)
An efficient synthesis of N-arylsulfonylindoles from indoles and arylsulfonyl chlorides in the presence of triethylbenzylammonium chloride (TEBA) and NaOH at room temperature is described.
Anti human immunodeficiency virus-1 (HIV-1) agents 3. Synthesis and in vitro anti-HIV-1 activity of some N-arylsulfonylindoles
Fan, Ling-Ling,Liu, Wu-Qing,Xu, Hui,Yang, Liu-Meng,Lv, Min,Zheng, Yong-Tang
experimental part, p. 797 - 800 (2010/02/27)
In order to find compounds with superior anti human immunodeficiency virus type 1 (HIV-1) activity, twelve simple N-arylsulfonylindoles (3a-l) were synthesized and preliminarily evaluated as HIV-1 inhibitors in vitro for the first time. Several compounds demonstrated significant anti-HIV-1 activity, especially N-(3-nitrobenzene) sulfonyl-6-methylindole (3h) and N-(3-nitrobenzene)sulfonylindole (3i) showed the highest anti-HIV-1 activity with EC50 values of 0.26 and 0.74 μg/ml, and TI values of 543.78 and >270.27, respectively.
