1194045-07-2

Upstream product

• 1007-15-4 4-fluoro-3-bromoacetophenone 
• 676-58-4 methylmagnesium chloride 

Downstream Products

• 1246248-64-5 3-(3-Bromo-4-fluorophenyl)but-3-en-1-ol 
• 1246248-65-6 {[3-(3-Bromo-4-fluorophenyl)but-3-en-1-yl]oxy}(tert-butyl)dimethylsilane 
• 1246248-67-8 (2R)-2-(3-Bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-hydroxybutyl methanesulfonate 
• 1246248-68-9 (2R)-1-Amino-2-(3-bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}butan-2-ol 
• 1246248-66-7 (2R)-2-(3-bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}butane-1,2-diol 

Relevant academic research and scientific papers

AMIDE DERIVATIVE

The present invention relates to a compound or a pharmacologically acceptable salt thereof that has an excellent antagonistic effect on a neurokinin NK1 receptor, a neurokinin NK2 receptor, and a muscarine M3 receptor and is useful as a therapeutic agent for bronchial asthma, chronic obstructive pulmonary disease, or the like. A compound represented by general formula (I): [wherein R1 represents a hydrogen atom, a C1-C6 alkyl group, or the like; R2 represents a hydrogen atom, a C1-C6 alkyl group, or the like; R3 represents a phenyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group A, or the like; R4 represents a phenyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group A, or the like; L1 represents a C1-C10 alkylene group or the like; L2 represents a carbonyl group, a group represneted by the formula -N(R5)-C(=O)-, a group represented by the formula -C(=O)-N(R5)-, or the like; R5 represents a hydrogen atom, a C1-C6 alkyl group, or the like; E represents a phenylene group that may be substituted with 1 to 4 group(s) independently selected from Substituent Group A, or the like; m is an integer of 1 to 4; n is an integer of 0 to 4; p is an integer of 0 to 2; q is an integer of 1 to 10; r is 1 or 2; s is 0 or 1; and Substituent Group A represents the group consisting of a halogen atom, a C1-C6 alkyl group, C1-C6 halogenated alkyl group, or the like] or a pharmacologically acceptable salt thereof.

BACE INHIBITORS

The present invention provides BACE inhibitors of Formula I: methods for their use, and intermediates and methods for their preparation.