119410-09-2

Basic information

• Product Name: 8-Chloro-6-methoxy-11-(1-methyl-4-piperidinyl)-11H-benzo<5,6>cyclohepta<1,2-b>pyridin-11-ol
• CAS NO: 119410-09-2
• Molecular Weight: 370.879
• Mol File: 119410-09-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 8-Chloro-6-methoxy-11-(1-methyl-4-piperidinyl)-11H-benzo<5,6>cyclohepta<1,2-b>pyridin-11-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Chloro-6-methoxy-11-(1-methyl-4-piperidinyl)-11H-benzo<5,6>cyclohepta<1,2-b>pyridin-11-ol(119410-09-2)
• EPA Substance Registry System: 8-Chloro-6-methoxy-11-(1-methyl-4-piperidinyl)-11H-benzo<5,6>cyclohepta<1,2-b>pyridin-11-ol(119410-09-2)

Safety Data

• Hazardous Substances Data: 119410-09-2(Hazardous Substances Data)

Upstream product

• 117811-22-0 8-Chloro-6-methoxy-11H-benzo<5,6>cyclohepta<1,2-b>pyridin-11-one 
• 63463-36-5 (1-methyl-4-piperidyl)magnesium chloride 
• 117811-16-2 8-chloro-11H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-one 
• 31251-41-9 8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one 

Downstream Products

• 119410-05-8 6-Hydroxydesloratadine 
• 119410-11-6 8-Chloro-5,11-dihydro-11-(1-methyl-4-piperidinylidene)-6H-benzo<5,6>cyclohepta<1,2-b>pyridin-6-one 

Relevant articles and documents

Hydroxylated Metabolites of Loratadine: An Example of Conformational Diastereomers Due to Atropisomerism

The structures of two metabolites of the nonsedating antihistamine loratadine (1) were confirmed by synthesis.The metabolites 3a and 3b, which are hydroxylated in the bridgehead, were each prepared from tricyclic ketone 8 in seven steps.Each of these compounds was found to exist as a pair of conformational diastereomers which interconvert slowly at room temperature.These conformers arise due to restricted conformational mobility inherent to the diarylcycloheptane ring system.