1194235-41-0

Basic information

• Product Name: Bortezomib Impurity 9
• Synonyms: Bortezomib Impurity 9;WXSBJLWLFBBGKF-LSQMVHIFSA-N;(R)-3-methyl-1-((S)-3-phenyl-2-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)propanamido)butylboronic acid
• CAS NO: 1194235-41-0
• Molecular Formula: C₂₈H₃₄BN₅O₅
• Molecular Weight: 531.41106
• Mol File: 1194235-41-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.227±0.06 g/cm3(Predicted)
• PKA: 9.69±0.43(Predicted)
• CAS DataBase Reference: Bortezomib Impurity 9(CAS DataBase Reference)
• NIST Chemistry Reference: Bortezomib Impurity 9(1194235-41-0)
• EPA Substance Registry System: Bortezomib Impurity 9(1194235-41-0)

Safety Data

• Hazardous Substances Data: 1194235-41-0(Hazardous Substances Data)

Usage

Uses

N-(2-Pyrazinylcarbonyl)-L-phenylalanyl-N-[(1R)-1-borono-3-methylbutyl]-L-phenylalaninamide is an impurity of Bortezomib (B675700) and a tripeptide boronic acid proteasome inhibitor used as an antitumor agent.

Upstream product

• 98-97-5 2-pyrazylcarboxylic acid 
• 73058-37-4 N-(2-pyrazinylcarbonyl)-L-phenylalanine methyl ester 
• 1194235-14-7 N-(2-pyrazinecarbonyl)-L-phenylalanine-L-phenylalanine 
• 114457-94-2 (S)-3-phenyl-2[(pyrazine-2-carbonyl)-amino]propionic acid 
• 1194235-01-2 (S)-methyl 3-phenyl-2-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)-propanoate 
• 1194235-28-3 (+)-pinanediol N-(2-pyrazinecarbonyl)-L-phenylalanine-L-phenylalanine-L-leucineboronate 

Relevant articles and documents

TRIPEPTIDE BORONIC ACID OR BORONIC ESTER, PREPARATIVE METHOD AND USE THEREOF

The present invention discloses proteasome inhibitors of tripeptide boronic acids or boronic esters represented by Formula (I), preparative method and use thereof. The proteasome inhibitors are therapeutical agents for treating malignant tumor, various nervous system degenerative diseases, muscle cachexia or diabetes, wherein the malignant tumor is leukemia, gastric cancer, hepatocarcinoma or nasopharyngeal carcinoma.