1194354-16-9Relevant academic research and scientific papers
O-Spiro C-aryl glucosides as novel sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors
Xu, Baihua,Lv, Binhua,Feng, Yan,Xu, Ge,Du, Jiyan,Welihinda, Ajith,Sheng, Zelin,Seed, Brian,Chen, Yuanwei
scheme or table, p. 5632 - 5635 (2010/04/05)
Two series of O-spiro C-aryl glucosides were synthesized and tested for inhibition of hSGLT1 and hSGLT2. 6′-O-Spiro C-aryl glucosides exhibited potent in vitro hSGLT2 inhibitory activity but 2′-O-spiro C-aryl glucosides showed no in vitro hSGLT2 inhibitory activity at a screening concentration of 1 μM.
