1261551-75-0Relevant academic research and scientific papers
Discovery and initial optimization of alkoxyanthranilic acid derivatives as inhibitors of HCV NS5B polymerase
Parcella, Kyle,Nickel, Andrew,Beno, Brett R.,Sheriff, Steven,Wan, Changhong,Wang, Ying-Kai,Roberts, Susan B.,Meanwell, Nicholas A.,Kadow, John F.
supporting information, p. 295 - 298 (2016/12/27)
Alkoxyanthranilic acid derivatives have been identified to inhibit HCV NS5B polymerase, binding in an allosteric site located at the convergence of the palm and thumb regions. Information from co-crystal structures guided the structural design strategy. Ultimately, two independent structural modifications led to a similar shift in binding mode that when combined led to a synergistic improvement in potency and the identification of inhibitors with sub-micromolar HCV NS5B binding potency.
O-Spiro C-aryl glucosides as novel sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors
Xu, Baihua,Lv, Binhua,Feng, Yan,Xu, Ge,Du, Jiyan,Welihinda, Ajith,Sheng, Zelin,Seed, Brian,Chen, Yuanwei
scheme or table, p. 5632 - 5635 (2010/04/05)
Two series of O-spiro C-aryl glucosides were synthesized and tested for inhibition of hSGLT1 and hSGLT2. 6′-O-Spiro C-aryl glucosides exhibited potent in vitro hSGLT2 inhibitory activity but 2′-O-spiro C-aryl glucosides showed no in vitro hSGLT2 inhibitory activity at a screening concentration of 1 μM.
