1194376-31-2

Usage

Uses

Used in Pharmaceutical Industry:
Tert-butyl 3-cyano-3-hydroxypyrrolidine-1-carboxylate is used as a key intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows for the formation of amide or ester bonds, facilitating the development of new drugs with improved therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical industry, tert-butyl 3-cyano-3-hydroxypyrrolidine-1-carboxylate serves as a crucial building block for the synthesis of agrochemical compounds. Its versatility and reactivity enable the creation of novel agrochemicals with enhanced efficacy and selectivity.
Used in Organic Synthesis:
Tert-butyl 3-cyano-3-hydroxypyrrolidine-1-carboxylate is used as a versatile starting material in organic synthesis. Its polarity and reactivity make it suitable for a wide range of reactions, allowing chemists to synthesize complex organic molecules with diverse applications.
Overall, tert-butyl 3-cyano-3-hydroxypyrrolidine-1-carboxylate is a valuable chemical building block with a wide range of applications in various industries, including pharmaceutical, agrochemical, and organic synthesis. Its unique structure and properties make it an essential component in the development of new and innovative compounds.

Upstream product

• 773837-37-9 sodium cyanide 
• 101385-93-7 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 7677-24-9 trimethylsilyl cyanide 
• 143-33-9 sodium cyanide 

Downstream Products

• 114214-73-2 3-aminomethyl-3-hydroxypyrrolidine-1-carboxylic acid tert-butyl ester 
• 942190-61-6 1-(tert-butyl) 3-methyl 3-hydroxypyrrolidine-1,3-dicarboxylate 

Relevant academic research and scientific papers

SPIRO-CONDENSED PYRROLIDINE DERIVATIVES AS DEUBIQUITYLATING ENZYMES (DUB) INHIBITORS

The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of Cezanne 1. The invention further relates to the use of DUB inhibitors in the treatment of cancer. (Figure (I))

COMPOUNDS USEFUL AS IMMUNOMODULATORS

The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

Bespoke SnAP reagents for the synthesis of c-substituted spirocyclic and bicyclic saturated N-heterocycles

The precise placement of C-substituents on bicyclic and spirocyclic N-heterocycles is readily achieved by the combination of aldehydes and new SnAP reagents. The substituted SnAP reagents are readily prepared from simple starting materials and couple with

HETEROCYCLIC COMPOUNDS AS NAV CHANNEL INHIBITORS AND USES THEREOF

The present invention relates to heterocyclic compounds of formula (I) wherein: Z1 is C(R)(R), C(O), C(S), or C(NR); 2 Z is C(R)(R), 0, S, SO, S02, or NR; X is -O-, -S-, -S02-, -SO-, -C(O)-, -C02-, -C(O)N(R)-, -NRC(O)-, -NRC(O) N(R)-, -NRSO2-, or -N(R)-; or X is absent; A is an optionally substituted C1_6 aliphatic, C5-10 aryl, 3-8 membered saturated or partially unsaturated carbocyclic ring, 3-7 membered heterocylic ring, or a 5-6 membered heteroaryl ring; Y is -CH2-, -O-, -S-, -S02-, -SO-, -C(O)-, -C02-, -C(O)N(R)-, -NRC(O)-, - NRC(O)N(R)-, -NRS02-, or -N(R)-; B is an optionally substituted C5-10 aryl or 5-6 membered heteroaryl ring; m is 0, 1, 2, or 3; n is 0, 1, 2, or 3; q is 0, 1, 2, or 3; and r is 1 or 2; and pharmaceutically acceptable compositions thereof, useful as Navl.6 inhibitors.

Spiro-rifamycin derivatives targeting RNA polymerase

Compounds of the current invention relate to rifamycin derivatives having antimicrobial activities, including activities against drug-resistant microorganisms. More specifically, compounds of the current invention relate to a series of novel spiro rifamycin derivatives which have demonstrated potent antimicrobial activity.