1194487-60-9Relevant academic research and scientific papers
Structure-based design of novel human Pin1 inhibitors (I)
Guo, Chuangxing,Hou, Xinjun,Dong, Liming,Dagostino, Eleanor,Greasley, Samantha,Ferre, RoseAnn,Marakovits, Joseph,Johnson, M. Catherine,Matthews, David,Mroczkowski, Barbara,Parge, Hans,VanArsdale, Todd,Popoff, Ian,Piraino, Joseph,Margosiak, Stephen,Thomson, James,Los, Gerrit,Murray, Brion W.
, p. 5613 - 5616 (2009)
Pin1 is a member of the cis-trans peptidyl-prolyl isomerase family with potential anti-cancer therapeutic value. Here we report structure-based de novo design and optimization of novel Pin1 inhibitors. Without a viable lead from internal screenings, we de
